Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1.1(CAG-Upp1,-GFP)Gp}
• Allele Name: targeted mutation 1.1, Giuseppe Pizzorno
• Allele ID: MGI:5494989
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gt(ROSA)26Sor^tm1.1(CAG-Upp1,-GFP)Gp/Gt(ROSA)26Sor^+	involves: C57BL/6 * FVB/N	MGI:5494998

Genotype
MGI:5494998

ht1

• Allelic Composition: Gt(ROSA)26Sor^{tm1.1(CAG-Upp1,-GFP)Gp}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased fatty acid beta-oxidation ( J:195165 )

• reduced in hepatocytes

• however, supplementation with uridine restores fatty acid beta-oxidation

liver/biliary system

microvesicular hepatic steatosis ( J:195165 )

• hepatic microvesicular steatosis in untreated mice

• however, supplementation with uridine suppresses steatosis

cellular

decreased fatty acid beta-oxidation ( J:195165 )

• reduced in hepatocytes

• however, supplementation with uridine restores fatty acid beta-oxidation