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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc10a4tm1Tigm
targeted mutation 1, Texas A&M Institute for Genomic Medicine
MGI:5495143
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Slc10a4tm1Tigm/Slc10a4tm1Tigm involves: 129S/SvEvBrd MGI:5495145


Genotype
MGI:5495145
hm1
Allelic
Composition
Slc10a4tm1Tigm/Slc10a4tm1Tigm
Genetic
Background
involves: 129S/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc10a4tm1Tigm mutation (0 available); any Slc10a4 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• spontaneous
• high-grade seizure in pilocarpine injected mice
• however, mice exhibit normal sensitivity to kainic acid induced status epilepticus
• hippocampal slices exhibit increased spontaneous gamma-oscillation and decreased threshold to cholinergic stimulation with carbachol compared with wild-type slices
• mice exhibit spontaneous spike discharge unlike wild-type mice
• mice exhibit increased sensitivity to pilocarpine-induced status epilepticus compared with wild-type mice
• however, normal sensitivity to kainic acid induced status epilepticus

behavior/neurological
• spontaneous
• high-grade seizure in pilocarpine injected mice
• however, mice exhibit normal sensitivity to kainic acid induced status epilepticus
• hippocampal slices exhibit increased spontaneous gamma-oscillation and decreased threshold to cholinergic stimulation with carbachol compared with wild-type slices
• mice exhibit spontaneous spike discharge unlike wild-type mice
• mice exhibit increased sensitivity to pilocarpine-induced status epilepticus compared with wild-type mice
• however, normal sensitivity to kainic acid induced status epilepticus





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory