All Phenotypes Krt1<tm1Tmm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Krt1^tm1Tmm
targeted mutation 1, Thomas M Magin
MGI:5495252

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Krt1^tm1Tmm/Krt1^tm1Tmm	involves: 129 * C57BL/6	MGI:5495259
cx2	Krt1^tm1Tmm/Krt1⁺ Krt10^tm2Tmm/Krt10^tm2Tmm	involves: 129P2/OlaHsd * BALB/c * C57BL/6	MGI:5495261
cx3	Krt1^tm1Tmm/Krt1^tm1Tmm Krt10^tm2Tmm/Krt10⁺	involves: 129P2/OlaHsd * BALB/c * C57BL/6	MGI:5495262
cx4	Krt1^tm1Tmm/Krt1^tm1Tmm Krt10^tm2Tmm/Krt10^tm2Tmm	involves: 129P2/OlaHsd * BALB/c * C57BL/6	MGI:5495260
cx5	Krt1^tm1Tmm/Krt1^tm1Tmm S100a9^tm1Nck/S100a9^tm1Nck	involves: 129P2/OlaHsd * C57BL/6	MGI:5509366
cx6	Il18^tm1Khe/Il18^tm1Khe Krt1^tm1Tmm/Krt1^tm1Tmm	involves: 129P2/OlaHsd * C57BL/6	MGI:5509364

Allelic Composition	Krt1^tm1Tmm/Krt1^tm1Tmm
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt1^tm1Tmm mutation (0 available); any Krt1 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:200244 )

integument

impaired skin barrier function ( J:200244 )

• 2-fold increase in trans-epidermal water loss

• however, outside-in epidermal barrier is normal

abnormal skin morphology ( J:200244 )

• mild skin defect

abnormal corneocyte envelope morphology ( J:200244 )

• reduced number of intact cornified envelopes

• however, treatment with IL18-blocking antibodies rescues number of intact cornified envelopes

immune system

abnormal circulating interleukin level ( J:200244 )

• increased IL33 in the serum of newborn mice

increased circulating interleukin-18 level ( J:200244 )

• in newborn mice but not epidermal extracts

abnormal interleukin secretion ( J:200244 )

• increased IL33 in epidermal extracts

cardiovascular system

abnormal vasculogenesis ( J:200244 )

• increased vascularization at the dermal/epidermal interface indicated by increased PECAM staining

increased vascular permeability ( J:200244 )

• leaky capillary in the lungs at P0

growth/size/body

weight loss ( J:200244 )

• mild postnatally

homeostasis/metabolism

abnormal circulating interleukin level ( J:200244 )

• increased IL33 in the serum of newborn mice

increased circulating interleukin-18 level ( J:200244 )

• in newborn mice but not epidermal extracts

impaired skin barrier function ( J:200244 )

• 2-fold increase in trans-epidermal water loss

• however, outside-in epidermal barrier is normal

nervous system

abnormal cerebellar granule layer morphology ( J:200244 )

• reduced

hematopoietic system

abnormal blood cell morphology/development ( J:200244 )

• in the lungs at P0

Allelic Composition	Krt1^tm1Tmm/Krt1⁺ Krt10^tm2Tmm/Krt10^tm2Tmm
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt10^tm2Tmm mutation (1 available); any Krt10 mutation (32 available)
Krt1^tm1Tmm mutation (0 available); any Krt1 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:197699 )

• mice die within the first hours after birth due to generalized multiple small and some extended lesions caused by mechanical load

integument

decreased skin tensile strength ( J:197699 )

• fragile skin upon mechanical load

• however, the water barrier remains intact

Allelic Composition	Krt1^tm1Tmm/Krt1^tm1Tmm Krt10^tm2Tmm/Krt10⁺
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:197699 )

• mice die within the first hours after birth due to generalized multiple small and some extended lesions caused by mechanical load

integument

decreased skin tensile strength ( J:197699 )

• fragile skin upon mechanical load

• however, the water barrier remains intact

Allelic Composition	Krt1^tm1Tmm/Krt1^tm1Tmm Krt10^tm2Tmm/Krt10^tm2Tmm
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:197699 )

• mice die within the first hours after birth due to generalized multiple small and some extended lesions caused by mechanical load

integument

abnormal epidermal layer morphology ( J:197699 )

• smaller desmosomes at E18.5 in the upper epidermis than in wild-type mice

abnormal corneocyte envelope morphology ( J:197699 )

• some are misshapen with inclusions or empty appearance

hyperkeratosis ( J:197699 )

• thick and disorganized with impaired cornified envelop differentiation

abnormal epidermis suprabasal layer morphology ( J:197699 )

• devoid of intermediate filaments

• flattened keratinocytes

• premature degradation of nuclei in suprabasal epidermis

decreased skin tensile strength ( J:197699 )

• fragile skin upon mechanical load

• however, the water barrier remains intact

Allelic Composition	Krt1^tm1Tmm/Krt1^tm1Tmm S100a9^tm1Nck/S100a9^tm1Nck
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt1^tm1Tmm mutation (0 available); any Krt1 mutation (68 available)
S100a9^tm1Nck mutation (0 available); any S100a9 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality, complete penetrance ( J:200244 )

• no survivors are generated

Allelic Composition	Il18^tm1Khe/Il18^tm1Khe Krt1^tm1Tmm/Krt1^tm1Tmm
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il18^tm1Khe mutation (0 available); any Il18 mutation (32 available)
Krt1^tm1Tmm mutation (0 available); any Krt1 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:200244 )

N	• lethality observed in Krt1^tm1Tmm heterozygotes is partially rescued

integument

integument phenotype ( J:200244 )

N	• normal epidermal morphology with normal numbers of intact cornified envelops

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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