All Phenotypes Gt(ROSA)26Sor<tm4(EWSR1/ATF1)Mrc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}
targeted mutation 4, Mario R Capecchi
MGI:5495288

Summary

11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺	involves: C57BL/6	MGI:5495300
cn2	Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5495301
cn3	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺ Bmi1^{tm1(cre/ERT)Mrc}/Bmi1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5495321
cn4	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺ Pax7^tm1(cre)Mrc/Pax7⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5495314
cn5	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺ Myf5^tm1(cre)Mrc/Myf5⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5495318
cn6	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺ Pax7^{tm1(cre/ERT2)Gaka}/Pax7⁺	involves: 129S6/SvEvTac * C57BL/6	MGI:5495319
cn7	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺ Pax3^tm1(cre)Joe/Pax3⁺	involves: C57BL/6	MGI:5495303
cn8	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺ Tg(Prrx1-cre/ERT2)1Mlgn/?	involves: C57BL/6	MGI:5495320
cn9	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: C57BL/6J * CBA/J	MGI:5495316
cn10	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺ Tg(Prrx1-cre)1Cjt/?	involves: C57BL/6 * SJL	MGI:5495317
cn11	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺ Tg(Tek-cre)1Ywa/?	involves: C57BL/6 * SJL	MGI:5495315

Allelic Composition	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc} mutation (0 available); any Gt(ROSA)26Sor mutation (994 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:194308 )

• injection of TAT-cre results in tumors at the injection site as well as EGFP expression

abnormal tumor morphology ( J:194308 )

• match human clear cell sarcoma tumor histomorphology and immunochemistry

• open chromatin and clear cytoplasm

increased tumor growth/size ( J:194308 )

• rapid tumor growth after visible detection regardless of latency

abnormal tumor latency ( J:194308 )

• latency of tumor formation correlated with TAT-cre concentration

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:194308 )

• injection of TAT-cre results in tumors at the injection site as well as EGFP expression

Allelic Composition	Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(cre/ERT)Nat} mutation (2 available); any Gt(ROSA)26Sor mutation (994 available)
Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc} mutation (0 available); any Gt(ROSA)26Sor mutation (994 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased litter size ( J:194308 )

growth/size/body

postnatal growth retardation ( J:194308 )

• administration of tamoxifen prior to 3 weeks of age results in stunted growth

mortality/aging

premature death ( J:194308 )

• administration of tamoxifen prior to 3 weeks of age results in death by 12 weeks of age without tumor formation

neoplasm

increased tumor incidence ( J:194308 )

• when tamoxifen is administered after 3 weeks of age more tumors form than without tamoxifen

• tumors most often in extremities, rib cage, and facial tissue

• tumors rare in dermis, liver, and bone

increased sarcoma incidence ( J:217462 )

• mice develop clear cell sarcoma mimicking tumors across a broad anatomic distribution at 3-6 months of age in the absence of tamoxifen, indicating leakiness of the cre transgene

increased tumor latency ( J:194308 )

• all mice have tumors by 12 weeks regardless of treatment

Allelic Composition	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺ Bmi1^{tm1(cre/ERT)Mrc}/Bmi1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmi1^{tm1(cre/ERT)Mrc} mutation (2 available); any Bmi1 mutation (31 available)
Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc} mutation (0 available); any Gt(ROSA)26Sor mutation (994 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:194308 )

• fully penetrant tumorigenesis when tamoxifen is injected after 3 weeks of age

• tumors in deep mesenchymal tissues of the limbs and trunk

• most tumors form adjacent to bone but some are totally in muscle

• all tumors with "clear cell" morphology

Allelic Composition	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺ Pax7^tm1(cre)Mrc/Pax7⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc} mutation (0 available); any Gt(ROSA)26Sor mutation (994 available)
Pax7^tm1(cre)Mrc mutation (2 available); any Pax7 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:194308 )

• live embryos at E18.5 but no live progeny

craniofacial

abnormal craniofacial morphology ( J:194308 )

• severe craniofacial deformation

Allelic Composition	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺ Myf5^tm1(cre)Mrc/Myf5⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc} mutation (0 available); any Gt(ROSA)26Sor mutation (994 available)
Myf5^tm1(cre)Mrc mutation (1 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:194308 )

• live to 3 months

growth/size/body

decreased body size ( J:194308 )

• mice are very small

muscle

myopathy ( J:194308 )

• severely myopathic

Allelic Composition	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺ Pax7^{tm1(cre/ERT2)Gaka}/Pax7⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc} mutation (0 available); any Gt(ROSA)26Sor mutation (994 available)
Pax7^{tm1(cre/ERT2)Gaka} mutation (1 available); any Pax7 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

myopathy ( J:194308 )

• when tamoxifen is administered after 3 weeks of age myopathy develops by 12 months

neoplasm

neoplasm ( J:194308 )

N	• no abnormal tumor development when treated with tamoxifen after 3 weeks of age

Allelic Composition	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺ Pax3^tm1(cre)Joe/Pax3⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc} mutation (0 available); any Gt(ROSA)26Sor mutation (994 available)
Pax3^tm1(cre)Joe mutation (1 available); any Pax3 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:194308 )

Allelic Composition	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺ Tg(Prrx1-cre/ERT2)1Mlgn/?
Genetic Background	involves: C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

myopathy ( J:194308 )

• when tamoxifen is administered after 3 weeks of age myopathy develops by 12 months

neoplasm

increased tumor incidence ( J:194308 )

• when tamoxifen is administered after 3 weeks of age tumors develop in the extremities of 100% of mice by 8 weeks of age

• tumors arise from the periosteal/perichondrial layer as well as within musculature

• clear cell morphology or spindle cell morphology

Allelic Composition	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc} mutation (0 available); any Gt(ROSA)26Sor mutation (994 available)
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:194308 )

Allelic Composition	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺ Tg(Prrx1-cre)1Cjt/?
Genetic Background	involves: C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:194308 )

• embryos are viable at E14.5 but with severe limb deformities

limbs/digits/tail

abnormal limb morphology ( J:194308 )

• severe limb deformities at E14.5

Allelic Composition	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺ Tg(Tek-cre)1Ywa/?
Genetic Background	involves: C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:194308 )

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