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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Unc5dtm1Kln
targeted mutation 1, Rudiger Klein
MGI:5495472
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Unc5dtm1Kln/Unc5dtm1Kln involves: 129S/SvEv * C57BL/6 MGI:5495543


Genotype
MGI:5495543
hm1
Allelic
Composition
Unc5dtm1Kln/Unc5dtm1Kln
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Unc5dtm1Kln mutation (0 available); any Unc5d mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• growth cone collapse response to FLRT2-Fc (constant region fragment; Fc), but not FLRT3-Fc, is impaired compared to in wild-type cortical neurons
• at E15.5, radial migration of a subpopulation of cortical neurons is accelerated compared to wild-type neurons

behavior/neurological
N
• mice exhibit normal behavior

cellular
• growth cone collapse response to FLRT2-Fc (constant region fragment; Fc), but not FLRT3-Fc, is impaired compared to in wild-type cortical neurons
• at E15.5, radial migration of a subpopulation of cortical neurons is accelerated compared to wild-type neurons





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory