Phenotypes associated with this allele

• Allele Symbol: Kif5a^tm1.2Noh
• Allele Name: targeted mutation 1.2, Nobutaka Hirokawa
• Allele ID: MGI:5495650
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Kif5a^tm1.1Noh/Kif5a^tm1.2Noh	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA	MGI:5495662
cn2	Kif5a^tm1.2Noh/Kif5a^tm1.2Noh Tg(Syn1-cre)671Jxm/0	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA	MGI:5495663

Genotype
MGI:5495662

ht1

• Allelic Composition: Kif5a^tm1.1Noh/Kif5a^tm1.2Noh
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:197666 )

• mice exhibit normal appearance, body size, brain morphology and behavior

Genotype
MGI:5495663

cn2

• Allelic Composition: Kif5a^tm1.2Noh/Kif5a^tm1.2Noh; Tg(Syn1-cre)671Jxm/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

mortality/aging

postnatal lethality, complete penetrance ( J:197666 )

• mice die at approximately 3 weeks postnatally

nervous system

nervous system phenotype ( J:197666 )

N • mice exhibit normal brain histology

seizures ( J:197666 )

• mice exhibit epileptic electroencephalography (EEG) and reduced EEG power during rest and locomotive states compared with control mice

abnormal GABA-mediated receptor currents ( J:197666 )

• impaired neurotransmission in the hippocampus with abnormal post-Golgi GABA receptor trafficking and localization

decreased miniature inhibitory postsynaptic current amplitude ( J:197666 )

• reduced mean amplitude with a shift to smaller amplitudes

• however, miniature inhibitory postsynaptic currents frequency, rise time and decay time are normal

growth/size/body

postnatal growth retardation ( J:197666 )

behavior/neurological

seizures ( J:197666 )

• mice exhibit epileptic electroencephalography (EEG) and reduced EEG power during rest and locomotive states compared with control mice