Analysis Tools
behavior/neurological
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• mice exhibit impaired fear memory acquisition, consolidation and retention compared with wild-type mice
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• mice exhibit impaired fear memory acquisition, consolidation and retention compared with wild-type mice
• mice exhibit impaired contextual discrimination or pattern separation in a contextual conditioning test
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• mice exhibit impaired contextual discrimination or pattern separation in a contextual conditioning test
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• severely impaired in a Barnes circular maze
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• impaired in an 8-arm radial maze test
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• shorter latency to fall in wire hang test
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• slightly
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• in a novel environment and Y-maze test
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• in an open field
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• female mice do not nurture pups
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• decreased in home cage but not in a novel environment
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nervous system
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• altered long term synaptic plasticity in young and old mice
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• altered synaptic transmission and plasticity in young and old mice
• young mice exhibit reduced ratio between the amplitude of the presynaptic fiber volley and the initial slope of the postsynaptic field excitatory postsynaptic potential compared with wild-type mice
• basal transmission of the medial perforant path-dentate gyrus synapses is attenuated in older mice
• however, mice exhibit normal long term depression
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• in young mice
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• increased magnitude following high-, intermediate- and lower-frequency stimulation in young mice
• robust at the medial preforant path-dentate gyrus synapses in young, but not old, mice
• increased in older mice induced with repeated tetanic stimulus
• however, long term potentiation induced by high-frequency stimulus in older mice is normal
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• reduced probability of neurotransmitter release in young and old mice
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• young and old mice exhibit larger paired pulse ratio than in wild-type mice
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growth/size/body
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• at 4 to 8 weeks
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cellular
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• homozygous mice rarely produce offspring and female mice do not nurture pups
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