mortality/aging
• half of mice are born alive
|
behavior/neurological
• adult mice exhibit impaired motor learning compared with wild-type mice
|
• in an elevated plus maze
|
• in an open field
|
• on a rotarod in young and adult mice with gradual improvement after weaning
• in the daytime, adult mice spend less time hanging than wild-type mice
|
• in daytime and nighttime
|
• dyskinesia
|
• apomorphine-treated mice exhibit increased activity and rearing compared with wild-type mice
|
• apomorphine-treated mice exhibit increased activity and rearing compared with wild-type mice
|
• poor maternal care
|
homeostasis/metabolism
• L-DOPA accumulates, especially in young mice
|
• in the brain
|
• lower norepinephrine levels in the brain
|
• in the brain
|
cardiovascular system
• in adult mice
|
• in adult mice
|
growth/size/body
• at P10 with gradual improvement after weaning
|
• from birth to weaning
|
vision/eye
nervous system
• lower DOPAC, HVA and 5-HIAA neurotransmitter metabolites in the brain
• adult neurotransmitter levels are higher than in infants
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
aromatic L-amino acid decarboxylase deficiency | DOID:0090123 |
OMIM:608643 |
J:197646 |