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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Palb2tm1.1Dli
targeted mutation 1.1, David M Livingston
MGI:5495825
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Palb2tm1.1Dli/Palb2tm1.1Dli involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 MGI:5495971
cn2
 		Palb2tm1.1Dli/Palb2tm1.1Dli
Trp53bp1tm1Jc/Trp53bp1tm1Jc
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 MGI:5495974
cn3
 		Palb2tm1.1Dli/Palb2tm1.1Dli
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)1Amc/0 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA MGI:5495972
cn4
 		Palb2tm1.1Dli/Palb2tm1.1Dli
Trp53tm1Brn/Trp53+
Tg(KRT14-cre)1Amc/0 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA MGI:5495973


Genotype
MGI:5495971
hm1
Allelic
Composition		 Palb2tm1.1Dli/Palb2tm1.1Dli
Genetic
Background		 involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Palb2tm1.1Dli mutation (1 available); any Palb2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryo phenotype ( J:197442 )
N
• mice are normal at E12.5




Genotype
MGI:5495974
cn2
Allelic
Composition		 Palb2tm1.1Dli/Palb2tm1.1Dli
Trp53bp1tm1Jc/Trp53bp1tm1Jc
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Palb2tm1.1Dli mutation (1 available); any Palb2 mutation (50 available)
Trp53bp1tm1Jc mutation (1 available); any Trp53bp1 mutation (100 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosome breakage ( J:197442 )
• the number of chromosomal aberrations (chromatid breaks, chromosome breaks and radial chromosomes) in B lymphocytes is increased by treatment with KU0058949 (PARP inhibitor) compared to in wild-type mice




Genotype
MGI:5495972
cn3
Allelic
Composition		 Palb2tm1.1Dli/Palb2tm1.1Dli
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)1Amc/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Palb2tm1.1Dli mutation (1 available); any Palb2 mutation (50 available)
Tg(KRT14-cre)1Amc mutation (2 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mouth tumor incidence ( J:197442 )
• in the oral mucosa
abnormal tumor morphology ( J:197442 )
• expanded spectrum of tissues affected by tumors compared to in Trp53tm1Brn/Trp53tm1Brn Tg(KRT14-cre)1Amc mice
decreased tumor latency ( J:197442 )
• mice develop mammary tumor faster than Trp53tm1Brn/Trp53tm1Brn Tg(KRT14-cre)1Amc mice

integument

digestive/alimentary system
increased mouth tumor incidence ( J:197442 )
• in the oral mucosa

endocrine/exocrine glands

craniofacial
increased mouth tumor incidence ( J:197442 )
• in the oral mucosa

growth/size/body
increased mouth tumor incidence ( J:197442 )
• in the oral mucosa




Genotype
MGI:5495973
cn4
Allelic
Composition		 Palb2tm1.1Dli/Palb2tm1.1Dli
Trp53tm1Brn/Trp53+
Tg(KRT14-cre)1Amc/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Palb2tm1.1Dli mutation (1 available); any Palb2 mutation (50 available)
Tg(KRT14-cre)1Amc mutation (2 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor latency ( J:197442 )
• mice develop mammary tumor faster than Trp53tm1Brn/Trp53+ Tg(KRT14-cre)1Amc mice

integument

endocrine/exocrine glands




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory