Analysis Tools
digestive/alimentary system
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• total parietal cell number remains unchanged following tamoxifen treatment
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• at 7 and 60 days after final tamoxifen injection, expansion of surface mucous cells (foveolar hyperplasia) is observed, but at 150 days, surface mucous cell numbers are comparable to controls
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• parietal cells do not function in mutants treated with tamoxifen; parietal cells do not secrete acid in response to histamine stimulation
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homeostasis/metabolism
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• in an acetic acid ulceration model, healing is delayed relative to controls at 7 days after ulcer induction (ulcer size is decreased in controls); granulation tissue below the ulcer is observed in controls but not in mutants 7 days after induction
• in contrast to control mice, mutants do not exhibit macrophage recruitment to the ulcer site 2 days after ulcer induction; macrophage numbers are increased in stomachs of injured controls, but not in mutants
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cardiovascular system
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• 7 days after acetic acid injury, control mice display an increase in new microvessels compared to PBS-treated controls, but PBS-treated mutants have significantly fewer CD31-positive microvessels relative to controls with no significant change after acetic acid injury
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