Phenotypes associated with this allele

• Allele Symbol: Stk40^tm1Nju
• Allele Name: targeted mutation 1, Model Animal Research Center of Nanjing University
• Allele ID: MGI:5496282
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stk40^tm1Nju/Stk40^tm1Nju	B6.129-Stk40^tm1Nju	MGI:5496331

Genotype
MGI:5496331

hm1

• Allelic Composition: Stk40^tm1Nju/Stk40^tm1Nju
• Genetic Background: B6.129-Stk40^tm1Nju

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cyanosis and pulmonary atelectasis in Stk40^tm1Nju/Stk40^tm1Nju mice

mortality/aging

neonatal lethality, complete penetrance ( J:196001 )

• mice die within 12 hours of birth

respiratory system

increased lung apoptosis ( J:196001 )

• 2-fold higher apoptosis in the lungs at E18.5 compared to in wild-type mice

• however, apoptosis rates are normal at E15.5

increased lung glycogen level ( J:196001 )

• increased glycogen level in the lungs at E18.5

abnormal lung development ( J:196001 )

• lung maturation is delayed

• lung air space is lower than in wild-type mice

• however, cell proliferation in the lungs is normal

abnormal lung saccule morphology ( J:196001 )

• dilation is severely impaired with thicker septa than in wild-type mice

abnormal lung interstitium morphology ( J:196001 )

• thicker interstitial mesenchymal compartments at P0

small lung ( J:196001 )

• at E18.5

decreased lung weight ( J:196001 )

• at E18.5

abnormal pulmonary alveolar system morphology ( J:196001 )

• reduced alveolar space

atelectasis ( J:196001 )

• poorly expanded lobes with fissures at E18.5

• however, no hyaline membrane forms at P0

respiratory distress ( J:196001 )

• failure to initiate normal breathing despite deep respiratory movements involving the whole-body muscles immediately after birth

homeostasis/metabolism

cyanosis ( J:196001 )

• at birth

increased lung glycogen level ( J:196001 )

• increased glycogen level in the lungs at E18.5

cellular

increased lung apoptosis ( J:196001 )

• 2-fold higher apoptosis in the lungs at E18.5 compared to in wild-type mice

• however, apoptosis rates are normal at E15.5

growth/size/body

decreased body weight ( J:196001 )

• in pups