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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1Iaai
targeted mutation 1, Iannis Aifantis
MGI:5496396
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1Iaai/Gt(ROSA)26Sortm9(cre/ESR1)Arte involves: C57BL/6 * C57BL/6NTac MGI:5496424
cn2
 		Gt(ROSA)26Sortm1Iaai/Gt(ROSA)26Sor+
Ndor1Tg(UBC-cre/ERT2)1Ejb/0 		involves: 129S/SvEv * C57BL/6 MGI:5496425


Genotype
MGI:5496424
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1Iaai/Gt(ROSA)26Sortm9(cre/ESR1)Arte
Genetic
Background		 involves: C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Iaai mutation (0 available); any Gt(ROSA)26Sor mutation (997 available)
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (997 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal bone marrow cell physiology ( J:196407 )
• hematopoietic stem and progenitor cells (HSPCs) infected with MLL-AF9 and transplanted in lethally irradiated recipients treated with tamoxifen produce fewer white blood cells compared with control cells
• bone marrow HSPCs infected with MLL-AF9 or AML1-ETO and treated with tamoxifen exhibit reduced colony number and loss of blast colony morphology unlike control cells




Genotype
MGI:5496425
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1Iaai/Gt(ROSA)26Sor+
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Iaai mutation (0 available); any Gt(ROSA)26Sor mutation (997 available)
Ndor1Tg(UBC-cre/ERT2)1Ejb mutation (6 available); any Ndor1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal bone marrow cell physiology ( J:196407 )
• total bone marrow cells transplanted in lethally irradiated recipients and treated with tamoxifen induce a low abundant transient wave of CD4/CD8 double-positive T cells without inducing acute T cell leukemia (T-ALL) compared with control cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory