Phenotypes associated with this allele

• Allele Symbol: Homer1^tm1Kino
• Allele Name: targeted mutation 1, Kaoru Inokuchi
• Allele ID: MGI:5496433
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Homer1^tm1Kino/Homer1^tm1Kino	Not Specified	MGI:5496441

Genotype
MGI:5496441

hm1

• Allelic Composition: Homer1^tm1Kino/Homer1^tm1Kino
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:198336 )

N • mice exhibit normal memory acquisition and short term memory in contextual fear conditioning

N • mice exhibit normal memory extinction, general activity and emotional performance

impaired contextual conditioning behavior ( J:198336 )

• after 24 hours, reactivation of contextual freeze response with 1 minute of training is attenuated compared to in wild-type mice

• mice exhibit faster within-session freezing decrement compared with wild-type mice

• however, omission of re-exposure restores reactivation

abnormal long-term spatial reference memory ( J:198336 )

• memory consolidation is impaired compared to in wild-type mice

• mice exhibit impaired memory retention compared with wild-type mice

• reactivation memory becomes labile unlike in wild-type mice

• however, intense training rescues memory retention

abnormal touch/ nociception ( J:198336 )

• mice exhibit lower sensitivity to foot shock compared with wild-type mice

nervous system

abnormal dendrite morphology ( J:198336 )

• in the hippocampus CA1 region, mice exhibit a mildly rough and sparse dendritic layer that is worsened by maximum electroconvulsive shock (MECS) treatment compared with wild-type mice