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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tecpr1tm1Chsa
targeted mutation 1, Chihiro Sasakawa
MGI:5496539
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tecpr1tm1Chsa/Tecpr1tm1Chsa involves: 129S4/SvJae MGI:5496541


Genotype
MGI:5496541
hm1
Allelic
Composition		 Tecpr1tm1Chsa/Tecpr1tm1Chsa
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tecpr1tm1Chsa mutation (2 available); any Tecpr1 mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal autophagy ( J:198333 )
• mouse embryonic fibroblasts pulsed with puromycin exhibit reduced clearance of ubiquitinated protein aggregates and accumulation of depolarized mitochondria compared with wild-type cells
• however, non-selective autophagy is normal

immune system
abnormal susceptibility to infection ( J:198333 )
• mouse embryonic fibroblasts infected with Shigella delta icsB exhibit increased survival of bacteria compared with control cells

homeostasis/metabolism
abnormal autophagy ( J:198333 )
• mouse embryonic fibroblasts pulsed with puromycin exhibit reduced clearance of ubiquitinated protein aggregates and accumulation of depolarized mitochondria compared with wild-type cells
• however, non-selective autophagy is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory