Analysis Tools
integument
| N |
• mice exhibit normal transepidermal water loss
|
dermatitis
(
J:198332
)
|
• following exposure to croton oil, mice exhibit increased ear thickness, edema and inflammation compared with wild-type mice
• however, mice houses in specific pathogen free conditions do not develop dermatitis
|
|
• neonates exhibit crista cutis surrounded by deep furrows
|
|
• prone to desquamation under mechanical stress (tape stripping)
• keratin filaments exhibit abnormal aggregation compared to in wild-type mice
• mice exhibit increased penetration of foreign materials compared with wild-type mice
• the stratum corneum contains increased ceramide 2 and cholesterol compared with in wild-type mice
• however, mice exhibit normal corneodesmosomes, lamellar body secretion and extracellular lamellar bilayers
|
|
• compact hyperkeratosis in skin lesions
|
|
• with no abnormalities in lower layers
|
|
• the epidermis stratum corneum is prone to desquamation under mechanical stress (tape stripping)
|
scaly skin
(
J:198332
)
|
• in neonates
|
shiny skin
(
J:198332
)
|
• in neonates
|
skin lesions
(
J:198332
)
|
• with compact hyperkeratosis
|
immune system
|
• in response to ovalbumin with dibutyl phthalate exposure, mice exhibit increased IgG1 and IgE compared with wild-type mice
|
|
• in response to ovalbumin with dibutyl phthalate exposure
|
|
• in response to ovalbumin with dibutyl phthalate exposure
|
|
• mice exhibit enhanced immune responses to topically inoculated S. aureus compared to wild-type mice, showing robust skin infiltration of Th17 and gammadeltaT17 cells into the epidermis
• when mice are inoculated with S. aureus via an occlusive dressing technique that leads to the formation of dermatitis, mutant mice show aggravated dermatitis compared to wild-type mice
|
|
• following exposure to croton oil, mice exhibit increased ear thickness, edema and inflammation compared with wild-type mice
|
dermatitis
(
J:198332
)
|
• following exposure to croton oil, mice exhibit increased ear thickness, edema and inflammation compared with wild-type mice
• however, mice houses in specific pathogen free conditions do not develop dermatitis
|
homeostasis/metabolism
|
• the stratum corneum contains increased ceramide 3 and cholesterol compared with in wild-type mice
|
|
• the stratum corneum contains increased ceramide 2 and cholesterol compared with in wild-type mice
|
hematopoietic system
|
• in response to ovalbumin with dibutyl phthalate exposure
|
|
• in response to ovalbumin with dibutyl phthalate exposure
|
