Phenotypes associated with this allele

• Allele Symbol: Gdf15^tm1Breit
• Allele Name: targeted mutation 1, Samuel Breit
• Allele ID: MGI:5496693
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gdf15^tm1Breit/Gdf15^tm1Breit	B6.Cg-Gdf15^tm1Breit	MGI:5496794

Genotype
MGI:5496794

hm1

• Allelic Composition: Gdf15^tm1Breit/Gdf15^tm1Breit
• Genetic Background: B6.Cg-Gdf15^tm1Breit

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased lean body mass ( J:197174 )

♀ • females have significantly lower mean body mass at 12-14 weeks relative to age and sex-matched controls; male mutants and controls have similar lean body mass

increased body weight ( J:197174 )

• from 4 weeks through 1 year, both male and female mice are heavier than the respective controls (males 6% heavier, females 10% heavier)

adipose tissue

increased white adipose tissue amount ( J:197174 )

• male and female mice aged 14-16 weeks display significant increased total white adipose tissue mass (WATt) normalized to body weight

• no differences in tissue-specific lean mass (gastrocnemius and tibialis mucles) or brown adipose tissue are observed in males or females

increased total body fat amount ( J:197174 )

• at 12-14 weeks, both males and females have significantly higher total fat mass relative to controls

increased inguinal fat pad weight ( J:197174 )

• significant in males and females

increased mesenteric fat pad weight ( J:197174 )

• significant in males and females

increased retroperitoneal fat pad weight ( J:197174 )

• significant in males and females

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:197174 )

N • no differences in respiratory exchange ratios are detected between mutants and controls of either sex at 14-16 weeks of age

decreased energy expenditure ( J:197174 )

♀ • female mutants at 14-16 show significantly decreased energy expenditure, normalized to body weight; no differences are observed between male mutants and controls

abnormal basal metabolism ( J:197174 )

♀ • female mutants display a significantly lower basal metabolic rate compared to controls; no genotypic difference in basal metabolic rate of males (mutants vs controls) is observed

behavior/neurological

increased food intake ( J:197174 )

♀ • over a 3 day period, spontaneous cumulative food intake (13 weeks old) by female mutants is higher relative to control females, but mutant males and controls showed similar food intake

♀ • fasting-induced food intake on the same groups of mice (14 weeks old) showed no difference between mutants and controls of either sex; food intake during the light and dark phases showed no pattern differences between male and female mutants and controls

decreased locomotor activity ( J:197174 )

♀ • female mutants at 14-16 weeks show significantly lower physical activity during the dark phase relative to controls; no differences are observed between male mutants and controls