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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tsc2tm1.1Kcess
targeted mutation 1.1, Kevin C Ess
MGI:5496783
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tsc2tm1.1Kcess/Tsc2tm1.1Kcess involves: 129S1/SvImJ * 129S4/SvJaeSor * 129S6/SvEvTac MGI:5496786
cn2
 		Tsc2tm1.1Kcess/Tsc2tm1.1Kcess
Emx1tm1(cre)Krj/Emx1+ 		involves: 129S/Sv * C57BL/6J MGI:5496787


Genotype
MGI:5496786
hm1
Allelic
Composition		 Tsc2tm1.1Kcess/Tsc2tm1.1Kcess
Genetic
Background		 involves: 129S1/SvImJ * 129S4/SvJaeSor * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tsc2tm1.1Kcess mutation (1 available); any Tsc2 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:195049 )
• mice are indistinguishable from wild-type mice




Genotype
MGI:5496787
cn2
Allelic
Composition		 Tsc2tm1.1Kcess/Tsc2tm1.1Kcess
Emx1tm1(cre)Krj/Emx1+
Genetic
Background		 involves: 129S/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Tsc2tm1.1Kcess mutation (1 available); any Tsc2 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:195049 )
• mice start dying at P4 with complete lethality at P21
• however, rapamycin treatment rescues lethality

growth/size/body
decreased body weight ( J:195049 )
• however, treatment with rapamycin restores body weight
postnatal growth retardation ( J:195049 )
• during the first few days after birth

behavior/neurological
environmentally induced seizures ( J:195049 )
• prior to death in many mice during routine handling

nervous system
environmentally induced seizures ( J:195049 )
• prior to death in many mice during routine handling




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory