Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1.1(Aco1*)Mwh}
• Allele Name: targeted mutation 1.1, Matthias W Hentze
• Allele ID: MGI:5496785
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gt(ROSA)26Sor^tm1.1(Aco1*)Mwh/Gt(ROSA)26Sor^tm1.1(Aco1*)Mwh	B6.129P2(129S1)-Gt(ROSA)26Sor^tm1.1(Aco1*)Mwh	MGI:5499558

Genotype
MGI:5499558

hm1

• Allelic Composition: Gt(ROSA)26Sor^{tm1.1(Aco1*)Mwh}/Gt(ROSA)26Sor^{tm1.1(Aco1*)Mwh}
• Genetic Background: B6.129P2(129S1)-Gt(ROSA)26Sor^{tm1.1(Aco1*)Mwh}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:196374 )

N • mice are observed in Mendelian ratios, are fertile and reach adulthood without overt phenotypic abnormalities

hematopoietic system

abnormal erythropoiesis ( J:196374 )

• animals display impaired erythroid maturation; increases in the three earliest erythroid precursors (proerythroblasts and basophilic and polychromatophilic erythroblsasts) are observed with a 30% decrease in mature erythocytes

decreased erythrocyte cell number ( J:196374 )

• results in mild macrocytic anemia

decreased hematocrit ( J:196374 )

decreased hemoglobin content ( J:196374 )

increased mean corpuscular hemoglobin ( J:196374 )

• increases are slightly greater in female than males

increased mean corpuscular volume ( J:196374 )

• increases are slightly greater in female than males

increased spleen iron level ( J:196374 )

• levels are elevated 1.3 fold

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:196374 )

N • serum iron and ferritin levels are similar to controls

increased intestinal iron level ( J:196374 )

• in the duodenum, levels are elevated 1.5 fold

increased spleen iron level ( J:196374 )

• levels are elevated 1.3 fold

increased liver iron level ( J:196374 )

• levels are elevated 1.7 fold

digestive/alimentary system

increased intestinal iron level ( J:196374 )

• in the duodenum, levels are elevated 1.5 fold

immune system

increased spleen iron level ( J:196374 )

• levels are elevated 1.3 fold

liver/biliary system

increased liver iron level ( J:196374 )

• levels are elevated 1.7 fold