All Phenotypes Esrra<tm1.1Ics> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Esrra^tm1.1Ics
targeted mutation 1.1, Mouse Clinical Institute
MGI:5496789

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Esrra^tm1.1Ics/Esrra^tm1.1Ics Tg(Col1a1-cre)1Kry/0	involves: 129S2/SvPas * FVB	MGI:5496793

Allelic Composition	Esrra^tm1.1Ics/Esrra^tm1.1Ics Tg(Col1a1-cre)1Kry/0
Genetic Background	involves: 129S2/SvPas * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esrra^tm1.1Ics mutation (1 available); any Esrra mutation (25 available)
Tg(Col1a1-cre)1Kry mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal trabecular bone morphology ( J:195925 )

• ovariectomized female mice do not exhibit loss of bone volume, bone mineral density or trabecular thickness unlike control mice

• however, orchidectomized male mice exhibit normal loss of bone volume and bone mineral density

abnormal skeleton physiology ( J:195925 )

• ovariectomized female mice are protected from bone loss compared with control mice

• however, age-induced bone loss is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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