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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Twnktm1.2Lrsn
targeted mutation 1.2, Nils-Goran Larsson
MGI:5496876
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Twnktm1.2Lrsn/Twnktm1.2Lrsn involves: C57BL/6 MGI:5496889


Genotype
MGI:5496889
hm1
Allelic
Composition		 Twnktm1.2Lrsn/Twnktm1.2Lrsn
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Twnktm1.2Lrsn mutation (0 available); any Twnk mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:194965 )
• no viable homozygous pups are born, but other genotypes are represented in Mendelian numbers
embryonic lethality between somite formation and embryo turning, complete penetrance ( J:194965 )
• expected numbers of homozygous (~25%) embryos are found at E8.5 with all homozygotes having a mutant (and non-viable) appearance, suggesting that embryonic lethality occurs around E8.5

embryo




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory