Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^tm1Fan
• Allele Name: targeted mutation 1, Chen-Ming Fan
• Allele ID: MGI:5498471
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1Fan/Gt(ROSA)26Sor^+ Tg(T-cre)1Lwd/0	involves: C3H * C57BL/6 * C57BL/6J	MGI:5498472
cn2	Gt(ROSA)26Sor^tm1Fan/Gt(ROSA)26Sor^tm1Fan Tg(T-cre)1Lwd/0	involves: C3H * C57BL/6 * C57BL/6J	MGI:5498473

Genotype
MGI:5498472

cn1

• Allelic Composition: Gt(ROSA)26Sor^tm1Fan/Gt(ROSA)26Sor⁺; Tg(T-cre)1Lwd/0
• Genetic Background: involves: C3H * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cervical vertebrae fusions in Gt(ROSA)26Sor^tm1Fan/Gt(ROSA)26Sor⁺ Tg(T-cre)1Lwd/0 mice

skeleton

cervical vertebral fusion ( J:197427 )

• seen in approximately 40% of adults

Genotype
MGI:5498473

cn2

• Allelic Composition: Gt(ROSA)26Sor^tm1Fan/Gt(ROSA)26Sor^tm1Fan; Tg(T-cre)1Lwd/0
• Genetic Background: involves: C3H * C57BL/6 * C57BL/6J

Skeletal defects in Gt(ROSA)26Sor^tm1Fan/Gt(ROSA)26Sor^tm1Fan Tg(T-cre)1Lwd/0 mice

mortality/aging

neonatal lethality, complete penetrance ( J:197427 )

• die at birth

embryo

decreased somite size ( J:197427 )

• at E9.5

impaired somite development ( J:197427 )

• at E8.5 somite lose their compact epithelial morphology, instead cells display a scattered pattern

• poorly defined boundaries are seen along the body axis at E8.75

• lack well separated epithelia at E9.5

• at E11.5 long stretches of mesenchymal patches that fail to segregate into repeated intervals are seen

nervous system

fused dorsal root ganglion ( J:197427 )

abnormal spinal cord morphology ( J:197427 )

• axon bundles are not properly spaced

skeleton

abnormal axial skeleton morphology ( J:197427 )

• conspicuously defective along the cervical, trunk, and lumbar regions and to a lesser extent in the tail

abnormal intervertebral disk morphology ( J:197427 )

• loss of intervertebral disks

vertebral fusion ( J:197427 )

• fusions of the neural arches and vertebral bodies

limbs/digits/tail

kinked tail ( J:197427 )

• in neonates

behavior/neurological

abnormal posture ( J:197427 )

• straightened posture in neonates