Phenotypes associated with this allele

• Allele Symbol: Tg(Col1a1-FGF2*,-Sapphire)308Mmh
• Allele Name: transgene insertion 308, Marja M Hurley
• Allele ID: MGI:5498503
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Col1a1-FGF2*,-Sapphire)308Mmh/Tg(Col1a1-FGF2*,-Sapphire)308Mmh	involves: FVB/N	MGI:5498672

Genotype
MGI:5498672

tg1

• Allelic Composition: Tg(Col1a1-FGF2*,-Sapphire)308Mmh/Tg(Col1a1-FGF2*,-Sapphire)308Mmh
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Trabecular and cortical bone abnormalities in homozygous Tg(Col1a1-FGF2*,-Sapphire)305Mmh and Tg(Col1a1-FGF2*,-Sapphire)308Mmh mice

growth/size/body

increased body weight ( J:147213 )

♂ • 4.5 month old male homozygotes exhibit increased body weight as compared to control transgenics

limbs/digits/tail

increased femur compact bone thickness ( J:147213 )

♂ • circumferential thickness from femoral cortical bone is increased by 7% as compared to control transgenic

increased femoral compact bone area ( J:147213 )

♂ • segmented femoral cortical bone area is increased by 15% as compared to control transgenic

skeleton

abnormal bone marrow morphology ( J:147213 )

♂ • increased number and area of mineralized nodules in bone marrow stromal cell cultures

increased bone mineral content ( J:147213 )

♂ • tibial BMC is increased by 18% as compared to control transgenic

♂ • femoral BMC is increased by 12% as compared to control transgenic

increased bone mineral density ( J:147213 )

♂ • tibial BMD is increased by 12% as compared to control transgenic

increased bone mineral density of femur ( J:147213 )

♂ • femoral BMD is increased by 6% as compared to control transgenic

increased bone volume ( J:147213 )

♂ • BV/TV density is increased by 24% as compared to control transgenic

abnormal compact bone morphology ( J:147213 )

♂ • circumferential endosteal perimeter from femoral cortical bone is increased by 8% as compared to control transgenic

increased femur compact bone thickness ( J:147213 )

♂ • circumferential thickness from femoral cortical bone is increased by 7% as compared to control transgenic

increased femoral compact bone area ( J:147213 )

♂ • segmented femoral cortical bone area is increased by 15% as compared to control transgenic

abnormal periosteum morphology ( J:147213 )

♂ • circumferential periosteal perimeter from the femoral cortical bone is increased by 7% as compared to control transgenic

abnormal bone trabecula morphology ( J:147213 )

♂ • trabecular architecture is 12% more rod-like than the transgenic control as measured by Trl-SMI (a measure of plate versus rod architecture)

increased trabecular bone thickness ( J:147213 )

♂ • trabecular thickness is increased by 13% as compared to control transgenic