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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Col1a1-FGF2*,-Sapphire)305Mmh
transgene insertion 305, Marja M Hurley
MGI:5498524
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Col1a1-FGF2*,-Sapphire)305Mmh/Tg(Col1a1-FGF2*,-Sapphire)305Mmh involves: FVB/N MGI:5498652


Genotype
MGI:5498652
tg1
Allelic
Composition
Tg(Col1a1-FGF2*,-Sapphire)305Mmh/Tg(Col1a1-FGF2*,-Sapphire)305Mmh
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype

Trabecular and cortical bone abnormalities in homozygous Tg(Col1a1-FGF2*,-Sapphire)305Mmh and Tg(Col1a1-FGF2*,-Sapphire)308Mmh mice

growth/size/body
• 4.5 month old male homozygotes exhibit increased body weight as compared to control transgenic

limbs/digits/tail
• circumferential thickness from femoral cortical bone is increased by 7% as compared to control transgenic
• segmented femoral cortical bone area is increased by 17% as compared to control transgenic

skeleton
• increased number and area of mineralized nodules in bone marrow stromal cell cultures
• tibial BMC is increased by 29% as compared to control transgenic
• femoral BMC is increased by 22% as compared to control transgenic
• tibial BMD is increased by 16% as compared to control transgenic
• femoral BMD is increased by 8% as compared to control transgenic
• BV/TV density is increased by 19% as compared to control transgenic
• circumferential endosteal perimeter from femoral cortical bone is increased by 9% as compared to control transgenic
• circumferential thickness from femoral cortical bone is increased by 7% as compared to control transgenic
• segmented femoral cortical bone area is increased by 17% as compared to control transgenic
• circumferential periosteal perimeter from the femoral cortical bone is increased by 9% as compared to control transgenic
• femurs exhibit increased mineralized trabeculae
• trabecular architecture is 10% more rod-like than the transgenic control as measured by Trl-SMI (a measure of plate versus rod architecture)
• trabecular thickness is increased by 8% as compared to control transgenic





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory