growth/size/body
• 4.5 month old male homozygotes exhibit increased body weight as compared to control transgenic
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limbs/digits/tail
• circumferential thickness from femoral cortical bone is increased by 7% as compared to control transgenic
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• segmented femoral cortical bone area is increased by 17% as compared to control transgenic
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skeleton
• increased number and area of mineralized nodules in bone marrow stromal cell cultures
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• tibial BMC is increased by 29% as compared to control transgenic
• femoral BMC is increased by 22% as compared to control transgenic
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• tibial BMD is increased by 16% as compared to control transgenic
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• femoral BMD is increased by 8% as compared to control transgenic
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• BV/TV density is increased by 19% as compared to control transgenic
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• circumferential endosteal perimeter from femoral cortical bone is increased by 9% as compared to control transgenic
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• circumferential thickness from femoral cortical bone is increased by 7% as compared to control transgenic
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• segmented femoral cortical bone area is increased by 17% as compared to control transgenic
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• circumferential periosteal perimeter from the femoral cortical bone is increased by 9% as compared to control transgenic
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• femurs exhibit increased mineralized trabeculae
• trabecular architecture is 10% more rod-like than the transgenic control as measured by Trl-SMI (a measure of plate versus rod architecture)
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• trabecular thickness is increased by 8% as compared to control transgenic
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