Phenotypes associated with this allele

• Allele Symbol: Usp10^tm1Fuj
• Allele Name: targeted mutation 1, Masahiro Fujii
• Allele ID: MGI:5498660
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Usp10^tm1Fuj/Usp10^tm1Fuj	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:5498661

Genotype
MGI:5498661

hm1

• Allelic Composition: Usp10^tm1Fuj/Usp10^tm1Fuj
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell morphology ( J:194412 )

• MEFs treated with arsenite produce fewer and smaller stress granules than do controls

• stress granules disappear more rapidly than in controls

increased apoptosis ( J:194412 )

oxidative stress ( J:194412 )

• levels of reactive oxygen species (ROS) at 30 minutes after arsenite treatment equivalent to controls

• ROS levels elevated relative to controls at 60 minutes after arsenite treatment