Phenotypes associated with this allele

• Allele Symbol: hipr
• Allele Name: highper
• Allele ID: MGI:5498673
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	hipr/hipr	involves: C57BL/6J	MGI:5498675

Genotype
MGI:5498675

hm1

• Allelic Composition: hipr/hipr
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:196485 )

N • mice exhibit normal activity in the home cage regardless of light phase, habituation to the open field, anxiety-like behavior and spontaneous alteration

enhanced behavioral response to cocaine ( J:196485 )

• in response to cocaine, mice exhibit hyperactivity and enhanced conditioned place preference behavior compared with wild-type mice

• mice exhibit increased response to cocaine at lower doses compared with wild-type mice

• however, corticosterone levels are not related to cocaine-induced hyperactivity

enhanced conditioned place preference behavior ( J:196485 )

• in response to cocaine

impaired contextual conditioning behavior ( J:196485 )

induced hyperactivity ( J:196485 )

• in response to cocaine, methylphenidate or alcohol, mice exhibit hyperactivity compared with wild-type mice

hyperactivity elicited by ethanol administration ( J:196485 )

homeostasis/metabolism

increased circulating corticosterone level ( J:196485 )

• in response to stress, mice exhibit prolonged stress-induced HPA activation with elevated corticosterone levels for longer than in wild-type mice

• however, corticosterone levels are not related to cocaine-induced hyperactivity