Phenotypes associated with this allele

• Allele Symbol: Aurka^tm1.2Sbsn
• Allele Name: targeted mutation 1.2, Subrata Sen
• Allele ID: MGI:5498678
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aurka^tm1.2Sbsn/Aurka^tm1.2Sbsn	involves: 129S7/SvEvBrd * C57BL/6	MGI:5498680

Genotype
MGI:5498680

hm1

• Allelic Composition: Aurka^tm1.2Sbsn/Aurka^tm1.2Sbsn
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:198479 )

• in culture, blastocyst die between days 4.5 and 6.5

• no mice are present at E8.5

• however, mice are present at E3.5

embryo

embryonic growth retardation ( J:198479 )

• at E3.5

decreased embryo size ( J:198479 )

• at E3.5

abnormal inner cell mass morphology ( J:198479 )

• irregular cells at E3.5

inner cell mass degeneration ( J:198479 )

• degenerating cells after 1 day in culture (E4.5)

cellular

abnormal cell nucleus morphology ( J:198479 )

• micronucleated cells at E3.5

abnormal mitosis ( J:198479 )

• E3.5 embryos exhibit cells with mitotic disarray (disorganized spindle, misaligned and lagging chromosomes and micronucleated cells) unlike wild-type cells

abnormal mitotic spindle morphology ( J:198479 )

• at E3.5

growth/size/body

embryonic growth retardation ( J:198479 )

• at E3.5

decreased embryo size ( J:198479 )

• at E3.5