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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Aurkatm1.2Sbsn
targeted mutation 1.2, Subrata Sen
MGI:5498678
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Aurkatm1.2Sbsn/Aurkatm1.2Sbsn involves: 129S7/SvEvBrd * C57BL/6 MGI:5498680


Genotype
MGI:5498680
hm1
Allelic
Composition
Aurkatm1.2Sbsn/Aurkatm1.2Sbsn
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aurkatm1.2Sbsn mutation (0 available); any Aurka mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no mice are present at E8.5
• in culture, blastocyst die between days 4.5 and 6.5
• however, mice are present at E3.5

embryo
• irregular cells at E3.5
• degenerating cells after 1 day in culture (E4.5)

cellular
• micronucleated cells at E3.5
• E3.5 embryos exhibit cells with mitotic disarray (disorganized spindle, misaligned and lagging chromosomes and micronucleated cells) unlike wild-type cells

growth/size/body





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory