mortality/aging
• no mice are present at E8.5
• in culture, blastocyst die between days 4.5 and 6.5
• however, mice are present at E3.5
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embryo
• at E3.5
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• at E3.5
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• irregular cells at E3.5
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• degenerating cells after 1 day in culture (E4.5)
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cellular
• micronucleated cells at E3.5
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• E3.5 embryos exhibit cells with mitotic disarray (disorganized spindle, misaligned and lagging chromosomes and micronucleated cells) unlike wild-type cells
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• at E3.5
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growth/size/body
• at E3.5
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• at E3.5
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