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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Il17ratm1.2Kurs
targeted mutation 1.2, Florian C Kurschus
MGI:5498882
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Il17ratm1.2Kurs/Il17ratm1.2Kurs involves: 129S4/SvJae * BALB/cJ * C57BL/6 * SJL MGI:5499095


Genotype
MGI:5499095
hm1
Allelic
Composition
Il17ratm1.2Kurs/Il17ratm1.2Kurs
Genetic
Background
involves: 129S4/SvJae * BALB/cJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17ratm1.2Kurs mutation (0 available); any Il17ra mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in untreated mice and mice treated with imiquimod-containing Aldara cream with an increase in IL17A expression
• in untreated mice and mice treated with imiquimod-containing Aldara cream
• of IL17+ cells in untreated mice without an increase after treatment with imiquimod-containing Aldara cream
• mice treated with imiquimod-containing Aldara cream exhibit increased CD4+ and gammadelta T cells expressing IL22 in the skin compared with wild-type mice
• in untreated mice and mice treated with imiquimod-containing Aldara cream
• in skin CD4+ T cells from mice treated with imiquimod-containing Aldara cream
• mice treated with imiquimod-containing Aldara cream exhibit increased frequency of CD11b+ cells in skin infiltrate compared with wild-type mice
• however, the composition of myeloid cellular infiltrates is normal

integument
• mice treated with imiquimod-containing Aldara cream exhibit increased frequency of CD11b+ cells in skin infiltrate compared with wild-type mice
• however, the composition of myeloid cellular infiltrates is normal
• mice treated with imiquimod-containing Aldara cream exhibit mild reduction of psoriasis-like disease (skin redness, epidermal hyperplasia, thickness and scaling) compared with wild-type mice
• however, the composition of myeloid cellular infiltrates is normal

hematopoietic system
• in untreated mice and mice treated with imiquimod-containing Aldara cream with an increase in IL17A expression
• in untreated mice and mice treated with imiquimod-containing Aldara cream
• of IL17+ cells in untreated mice without an increase after treatment with imiquimod-containing Aldara cream





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory