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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pros1tm1Grl
targeted mutation 1, Greg Lemke
MGI:5499097
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pros1tm1Grl/Pros1tm1Grl involves: 129S1/SvImJ MGI:5499114
cn2
 		Pros1tm1Grl/Pros1tm1Grl
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129S1/SvImJ * C57BL/6 * DBA MGI:5499118
cn3
 		Pros1tm1Grl/Pros1tm1Grl
Tg(Tek-cre)1Ywa/0 		involves: 129S1/SvImJ * C57BL/6 * SJL MGI:5499117
cn4
 		Pros1tm1Grl/Pros1tm1Grl
Tg(Tagln-cre)1Her/0 		involves: 129S1/SvImJ * C57BL/6 * SJL MGI:5499119


Genotype
MGI:5499114
hm1
Allelic
Composition		 Pros1tm1Grl/Pros1tm1Grl
Genetic
Background		 involves: 129S1/SvImJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pros1tm1Grl mutation (1 available); any Pros1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:198769 )
• mice are indistinguishable from wild-type mice




Genotype
MGI:5499118
cn2
Allelic
Composition		 Pros1tm1Grl/Pros1tm1Grl
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pros1tm1Grl mutation (1 available); any Pros1 mutation (44 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:198769 )
N
• mice appear grossly normal at E17.5 and adult mice are viable

cardiovascular system
cardiovascular system phenotype ( J:198769 )
N
• clot-containing blood vessels are well-organized and normal in appearance with intact structure

homeostasis/metabolism
abnormal thrombosis ( J:198769 )
• focal fibrin deposits detected in blood vessels at E15.5 to E17.5 with vascular occlusion or hemorrhage




Genotype
MGI:5499117
cn3
Allelic
Composition		 Pros1tm1Grl/Pros1tm1Grl
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pros1tm1Grl mutation (1 available); any Pros1 mutation (44 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:198769 )
N
• embryos and adults are viable

cardiovascular system
cardiovascular system phenotype ( J:198769 )
N
• mice exhibit normal vascular permeability in the liver

homeostasis/metabolism
abnormal thrombosis ( J:198769 )
• focal fibrin deposits are not associated with vascular occlusion or hemorrhage




Genotype
MGI:5499119
cn4
Allelic
Composition		 Pros1tm1Grl/Pros1tm1Grl
Tg(Tagln-cre)1Her/0
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pros1tm1Grl mutation (1 available); any Pros1 mutation (44 available)
Tg(Tagln-cre)1Her mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory