About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pros1tm1Grl
targeted mutation 1, Greg Lemke
MGI:5499097
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pros1tm1Grl/Pros1tm1Grl involves: 129S1/SvImJ MGI:5499114
cn2
 		Pros1tm1Grl/Pros1tm1Grl
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129S1/SvImJ * C57BL/6 * DBA MGI:5499118
cn3
 		Pros1tm1Grl/Pros1tm1Grl
Tg(Tek-cre)1Ywa/0 		involves: 129S1/SvImJ * C57BL/6 * SJL MGI:5499117
cn4
 		Pros1tm1Grl/Pros1tm1Grl
Tg(Tagln-cre)1Her/0 		involves: 129S1/SvImJ * C57BL/6 * SJL MGI:5499119


Genotype
MGI:5499114
hm1
Allelic
Composition		 Pros1tm1Grl/Pros1tm1Grl
Genetic
Background		 involves: 129S1/SvImJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pros1tm1Grl mutation (1 available); any Pros1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:198769 )
• mice are indistinguishable from wild-type mice




Genotype
MGI:5499118
cn2
Allelic
Composition		 Pros1tm1Grl/Pros1tm1Grl
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pros1tm1Grl mutation (1 available); any Pros1 mutation (44 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:198769 )
N
• mice appear grossly normal at E17.5 and adult mice are viable

cardiovascular system
cardiovascular system phenotype ( J:198769 )
N
• clot-containing blood vessels are well-organized and normal in appearance with intact structure

homeostasis/metabolism
abnormal thrombosis ( J:198769 )
• focal fibrin deposits detected in blood vessels at E15.5 to E17.5 with vascular occlusion or hemorrhage




Genotype
MGI:5499117
cn3
Allelic
Composition		 Pros1tm1Grl/Pros1tm1Grl
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pros1tm1Grl mutation (1 available); any Pros1 mutation (44 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:198769 )
N
• embryos and adults are viable

cardiovascular system
cardiovascular system phenotype ( J:198769 )
N
• mice exhibit normal vascular permeability in the liver

homeostasis/metabolism
abnormal thrombosis ( J:198769 )
• focal fibrin deposits are not associated with vascular occlusion or hemorrhage




Genotype
MGI:5499119
cn4
Allelic
Composition		 Pros1tm1Grl/Pros1tm1Grl
Tg(Tagln-cre)1Her/0
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pros1tm1Grl mutation (1 available); any Pros1 mutation (44 available)
Tg(Tagln-cre)1Her mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory