normal phenotype
• mice are viable and fertile and do not present any overt phenotype
|
Allele Symbol Allele Name Allele ID |
Pik3r4tm1.1Mpnd targeted mutation 1.1, Mario Pende MGI:5499157 |
||||||||||||||||||||||||||||||||
Summary |
7 genotypes
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice are viable and fertile and do not present any overt phenotype
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• in utero electroporation with a cre recombinase at E14.5 causes a severe cortical neuronal migration defect
|
• in utero electroporation with a cre recombinase at E14.5 causes a severe cortical neuronal migration defect
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mouse embryonic fibroblasts treated with a cre-expressing adenovirus exhibit compromised autophagy flux compared with control cells
• however, treated MEFs exhibit normal autophagosome formation
|
• mouse embryonic fibroblasts treated with a cre-expressing adenovirus exhibit compromised autophagy flux compared with control cells
• however, treated MEFs exhibit normal autophagosome formation
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• pyramidal cell layer is fractured
|
• increase in the number of ectopic pyramidal cells in the stratum oriens layer
|
• the stratum oriens layer contains ectopic pyramidal cells
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• pyramidal cell layer is fractured
|
• increase in the number of ectopic pyramidal cells in the stratum oriens layer
|
• the stratum oriens layer contains ectopic pyramidal cells
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• the hippocampus is barely discernible, with no structured pyramidal cell layer or dentate gyrus at P0 and P11
• the severe, progressive degeneration of the hippocampus is associated with caspase-induced apoptosis
|
• severe, progressive degeneration of the cortex that is associated with caspase-induced apoptosis
|
• reduction in cortical thickness at P0 that is more severe at P11
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• as early as 2 months of age
|
• as early as 2 months of age
|
• as early as 2 months of age
|
• severe muscular degeneration (with necrotic fibers, cell infiltration and centronucleated fibers) as early as 2 months of age
• more pronounced in fast twitch muscles compared to in mice with muscle-specific knock-out of Atg7tm1Tchi
|
• reduced force from the gastrocnemius of mice subjected to stimulation of the sciatic nerve
|
• compromised in muscles with accumulation of autophagosomes and lysosomes
|
• compromised in muscles with accumulation of autophagosomes and lysosomes
|
• 8-fold
|
• as early as 2 months of age
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 07/02/2024 MGI 6.13 |
|
|