Phenotypes associated with this allele

• Allele Symbol: Nos3^tm2.1Plh
• Allele Name: targeted mutation 2.1, Paul L Huang
• Allele ID: MGI:5499171
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nos3^tm2.1Plh/Nos3^tm2.1Plh	involves: 129S4/SvJae * C57BL/6	MGI:5499176

Genotype
MGI:5499176

hm1

• Allelic Composition: Nos3^tm2.1Plh/Nos3^tm2.1Plh
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating insulin level ( J:198075 )

• in mice fed a high fat diet

increased circulating leptin level ( J:198075 )

• in fasting mice fed a high fat diet

increased circulating LDL cholesterol level ( J:198075 )

• increased small low-density lipoprotein (sLDL) and low-density lipoprotein (LDL) cholesterol mice fed a high fat diet

increased circulating free fatty acids level ( J:198075 )

• non-esterified fatty acid in mice fed standard chow

insulin resistance ( J:198075 )

• in mice fed standard chow

decreased adiponectin level ( J:198075 )

• in fasting mice whether fed standard chow or a high fat diet

adipose tissue

increased brown adipose tissue amount ( J:198075 )

• in mice fed a high fat diet

increased white fat cell size ( J:198075 )

• compared to in Nos3^tm3.1Plh homozygotes

increased inguinal fat pad weight ( J:198075 )

• in mice fed a high fat diet

increased retroperitoneal fat pad weight ( J:198075 )

• in mice fed a high fat diet

cardiovascular system

increased mean systemic arterial blood pressure ( J:198075 )

decreased vasodilation ( J:198075 )

• in response to acetylcholine

growth/size/body

increased susceptibility to weight gain ( J:198075 )

• in mice fed a high fat diet

increased liver weight ( J:198075 )

• in mice fed a high fat diet

liver/biliary system

increased liver weight ( J:198075 )

• in mice fed a high fat diet

muscle

decreased vasodilation ( J:198075 )

• in response to acetylcholine