All Phenotypes Sirt2<tm1.2Auw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sirt2^tm1.2Auw
targeted mutation 1.2, Johan Auwerx
MGI:5499209

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Sirt2^tm1.2Auw/Sirt2^tm1.2Auw Tg(SOD1*G93A)1Gur/0	involves: 129 * C57BL/6 * C57BL/6J * SJL	MGI:5499286

Allelic Composition	Sirt2^tm1.2Auw/Sirt2^tm1.2Auw Tg(SOD1*G93A)1Gur/0
Genetic Background	involves: 129 * C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt2^tm1.2Auw mutation (0 available); any Sirt2 mutation (27 available)
Tg(SOD1*G93A)1Gur mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:194977 )

• as in Tg(SOD1*G93A)1Gur mice

nervous system

abnormal innervation pattern to muscle ( J:194977 )

• reduced innervation as in Tg(SOD1*G93A)1Gur mice

decreased neuron number ( J:194977 )

• as in Tg(SOD1*G93A)1Gur mice

abnormal action potential ( J:194977 )

• reduced compound action potential amplitudes as in Tg(SOD1*G93A)1Gur mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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