About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kdm6atm1.2Afst
targeted mutation 1.2, A Stewart
MGI:5499291
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kdm6atm1.2Afst/Kdm6atm1.2Afst involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 MGI:5499568
ot2
 		Kdm6atm1.2Afst/Y involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 MGI:5499567


Genotype
MGI:5499568
hm1
Allelic
Composition		 Kdm6atm1.2Afst/Kdm6atm1.2Afst
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6atm1.2Afst mutation (0 available); any Kdm6a mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
abnormal embryo development ( J:196401 )
• some embryos have abnormal morphology at E8.5
embryonic growth retardation ( J:196401 )
• at E9.5 and E10.5

cardiovascular system
abnormal heart development ( J:196401 )
• cardiac malformations at E9.5

craniofacial
cranioschisis ( J:196401 )
• at E9.5 and E10.5

growth/size/body
embryonic growth retardation ( J:196401 )
• at E9.5 and E10.5

skeleton
cranioschisis ( J:196401 )
• at E9.5 and E10.5




Genotype
MGI:5499567
ot2
Allelic
Composition		 Kdm6atm1.2Afst/Y
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6atm1.2Afst mutation (0 available); any Kdm6a mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:196401 )
• fewer than expected mice are present at birth

embryo

cardiovascular system

growth/size/body
embryonic growth retardation ( J:196401 )
• in some mice

craniofacial
cranioschisis ( J:196401 )
• in some mice at E9.5 and E13.5

skeleton
cranioschisis ( J:196401 )
• in some mice at E9.5 and E13.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory