Analysis Tools
growth/size/body
| N |
• mice are phenotypically normal and show no differences in size or weight relative to controls at birth or throughout their lifespan
|
craniofacial
| N |
• animals have normal tooth eruption
|
skeleton
|
• numbers of osteoclasts in the primary spongiosa are significantly increased at 6 weeks
|
|
• in vitro differentiated osteoclasts plate on dentin slices display decreased bone resorpion activity (45% lower osteoclastic resorption activity); osteoclasts show impaired resorption in vivo also
|
|
• tibial bone volume is increased by 24% compared to controls at 6 weeks
|
|
• trabecular thickness of tibiae at 6 weeks is increased by 44% compared to controls
|
hematopoietic system
|
• numbers of osteoclasts in the primary spongiosa are significantly increased at 6 weeks
|
|
• in vitro differentiated osteoclasts plate on dentin slices display decreased bone resorpion activity (45% lower osteoclastic resorption activity); osteoclasts show impaired resorption in vivo also
|
immune system
|
• numbers of osteoclasts in the primary spongiosa are significantly increased at 6 weeks
|
|
• in vitro differentiated osteoclasts plate on dentin slices display decreased bone resorpion activity (45% lower osteoclastic resorption activity); osteoclasts show impaired resorption in vivo also
|
