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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ilktm2Star
targeted mutation 2, Rene St-Arnaud
MGI:5499793
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ilktm1Star/Ilktm2Star
Tg(Acp5-cre)1Star/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5502225
cx2
 		Ilktm2Star/Ilk+
Itgb3tm1Hyn/Itgb3+ 		involves: 129S2/SvPas * C57BL/6 MGI:5502226


Genotype
MGI:5502225
cn1
Allelic
Composition		 Ilktm1Star/Ilktm2Star
Tg(Acp5-cre)1Star/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ilktm1Star mutation (1 available); any Ilk mutation (18 available)
Ilktm2Star mutation (0 available); any Ilk mutation (18 available)
Tg(Acp5-cre)1Star mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:197593 )
N
• mice are phenotypically normal and show no differences in size or weight relative to controls at birth or throughout their lifespan

craniofacial
craniofacial phenotype ( J:197593 )
N
• animals have normal tooth eruption

skeleton
increased osteoclast cell number ( J:197593 )
• numbers of osteoclasts in the primary spongiosa are significantly increased at 6 weeks
abnormal osteoclast physiology ( J:197593 )
• in vitro differentiated osteoclasts plate on dentin slices display decreased bone resorpion activity (45% lower osteoclastic resorption activity); osteoclasts show impaired resorption in vivo also
increased bone volume ( J:197593 )
• tibial bone volume is increased by 24% compared to controls at 6 weeks
increased trabecular bone thickness ( J:197593 )
• trabecular thickness of tibiae at 6 weeks is increased by 44% compared to controls

hematopoietic system
increased osteoclast cell number ( J:197593 )
• numbers of osteoclasts in the primary spongiosa are significantly increased at 6 weeks
abnormal osteoclast physiology ( J:197593 )
• in vitro differentiated osteoclasts plate on dentin slices display decreased bone resorpion activity (45% lower osteoclastic resorption activity); osteoclasts show impaired resorption in vivo also

immune system
increased osteoclast cell number ( J:197593 )
• numbers of osteoclasts in the primary spongiosa are significantly increased at 6 weeks
abnormal osteoclast physiology ( J:197593 )
• in vitro differentiated osteoclasts plate on dentin slices display decreased bone resorpion activity (45% lower osteoclastic resorption activity); osteoclasts show impaired resorption in vivo also




Genotype
MGI:5502226
cx2
Allelic
Composition		 Ilktm2Star/Ilk+
Itgb3tm1Hyn/Itgb3+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ilktm2Star mutation (0 available); any Ilk mutation (18 available)
Itgb3tm1Hyn mutation (6 available); any Itgb3 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
increased trabecular bone thickness ( J:197593 )
• mice display significant increase in thickness of the trabeculae at the primary spongiosa




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory