Phenotypes associated with this allele

• Allele Symbol: Drd2^tm1Smoc
• Allele Name: targeted mutation 1, Shanghai Model Organisms Center
• Allele ID: MGI:5499882
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Drd2^tm1Smoc/Drd2^tm1Smoc Tg(GFAP-cre)25Mes/0	involves: C57BL/6 * FVB/N	MGI:5499900

Genotype
MGI:5499900

cn1

• Allelic Composition: Drd2^tm1Smoc/Drd2^tm1Smoc; Tg(GFAP-cre)25Mes/0
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:194407 )

N • MPTP treated mice exhibit normal astrocyte proliferation in the substantia nigra

N • mice exhibit normal development of dopaminergic neurons in the ventral tagmental area

astrocytosis ( J:194407 )

• in the substantia nigra

abnormal astrocyte physiology ( J:194407 )

• mild increase in the production of pro-inflammatory mediator RNAs