Analysis Tools
homeostasis/metabolism
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• at 4 and 12 weeks, female mice fed a high cholesterol diet exhibit lower levels compared with Apoetm1Khw homozygotes fed a high cholesterol diet
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• in mice fed a high cholesterol diet compared with Apoetm1Khw homozygotes fed a high cholesterol diet
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• at least 2-fold in mice fed a high cholesterol diet
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• female mice fed a high cholesterol diet develop hypercholesterolemia faster than male mice
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• macrophages release increased ApoE compared with macrophages from Apoetm1Rraf homozygotes
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cardiovascular system
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• in the descending aorta of mice fed a high cholesterol diet compared with Apoetm1Khw homozygotes fed a high cholesterol diet
• however, lesion formation in the aortic arch is equivalent
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immune system
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• leukocyte levels are not altered
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