Phenotypes associated with this allele

• Allele Symbol: Slc25a23^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:5500043
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc25a23^tm1Lex/Slc25a23^tm1Lex	involves: 129 * C57BL/6	MGI:5500044

Genotype
MGI:5500044

hm1

• Allelic Composition: Slc25a23^tm1Lex/Slc25a23^tm1Lex
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mitochondrial physiology ( J:196890 )

• liver mitochondrial exhibit reduced calcium retention capacity in the presence of ATP compared with wild-type mitochondria

• liver mitochondria respiring succinate and stimulated by adenosine diphosphate in the presence of calcium or depleted from adenosine nucleotides and incubated with rotenone plus succinate exhibit reduced respiratory control ratio compared with wild-type mitochondria

• under conditions of agonist-induced stimulation, coupled respiration or maximal respiratory capacity, liver mitochondria exhibit reduced oxygen consumption rates in the presence of glucagon or phenylephrine compared with wild-type mitochondria

• liver mitochondria exhibit impaired glucagon-stimulated adenine nucleotide uptake and increase in calcium retention capacity and respiratory activity compared to wild-type mitochondria

homeostasis/metabolism

decreased urine urea nitrogen level ( J:196890 )

renal/urinary system

decreased urine urea nitrogen level ( J:196890 )