All Phenotypes Arhgef26<tm1.1Kbur> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Arhgef26^tm1.1Kbur
targeted mutation 1.1, Keith Burridge
MGI:5500046

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arhgef26^tm1.1Kbur/Arhgef26^tm1.1Kbur	B6.Cg-Arhgef26^tm1.1Kbur	MGI:5500051
cx2	Apoe^tm1Unc/Apoe^tm1Unc Arhgef26^tm1.1Kbur/Arhgef26^tm1.1Kbur	B6.Cg-Arhgef26^tm1.1Kbur Apoe^tm1Unc	MGI:5500052

Allelic Composition	Arhgef26^tm1.1Kbur/Arhgef26^tm1.1Kbur
Genetic Background	B6.Cg-Arhgef26^tm1.1Kbur

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef26^tm1.1Kbur mutation (0 available); any Arhgef26 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal vascular endothelial cell morphology ( J:195919 )

• intimal endothelial cells exhibit reduced membrane protrusion after ICAM-1 crosslinking compared with wild-type cells

abnormal vascular endothelial cell physiology ( J:195919 )

• primary aortic endothelial cells exhibit defective activation of RhoG after ICAM-1 clustering compared with wild-type cells

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Arhgef26^tm1.1Kbur/Arhgef26^tm1.1Kbur
Genetic Background	B6.Cg-Arhgef26^tm1.1Kbur Apoe^tm1Unc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (158 available)
Arhgef26^tm1.1Kbur mutation (0 available); any Arhgef26 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:195919 )

• in the aortic arch descending thoracic aorta of mice fed a western diet compared with Apoe^tm1Unc homozygotes

• however, mice fed standard chow do not exhibit a significant difference

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