All Phenotypes Rps7<Zma> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Rps7^Zma/Rps7⁺	C3.C(Cg)-Rps7^Zma	MGI:5500167
ht2	Rps7^Zma/Rps7⁺	involves: BALB/c * C3H/HeH * C57BL/6J	MGI:5500164
cx3	Rps7^Zma/Rps7⁺ Sox10^tm1Weg/Sox10⁺	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C3H/HeH	MGI:5500163
cx4	Rps7^Zma/Rps7⁺ Trp53^tm1Tyj/Trp53⁺	involves: 129S2/SvPas * BALB/c * C3H/HeH * C57BL/6J	MGI:5500165
cx5	Rps7^Zma/Rps7⁺ Tg(Dct-lacZ)IPav/0	involves: BALB/c * C3H/HeH * C57BL/6J * FVB/N	MGI:5500166

Allelic Composition	Rps7^Zma/Rps7⁺
Genetic Background	C3.C(Cg)-Rps7^Zma

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps7^Zma mutation (0 available); any Rps7 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:195156 )

N	• mice exhibit normal survival

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Skeletal abnormalities in Rps7^Zma/Rps7⁺ mutants

mortality/aging

premature death ( J:195156 )

• 74% viability

• Background Sensitivity: subsequent backcrossing to C57BL/6J resulted in complete lethality with no mice observed at N4

• Background Sensitivity: subsequent backcrossing to C3H/HeH lowers lethality to zero by N3

perinatal lethality ( J:195156 )

• Background Sensitivity: on a C57BL/6J background (no generation given)

skeleton

decreased caudal vertebrae number ( J:195156 )

• 16 to 19 versus 20 to 22 in wild-type mice

abnormal sternebra morphology ( J:195156 )

• shortened first sternebrae

asymmetric sternocostal joints ( J:195156 )

increased rib number ( J:195156 )

• small partial rib on C7 in some mice

cervical vertebral transformation ( J:195156 )

• C7 to T1 in some mice

lumbar vertebral transformation ( J:195156 )

• L1 to T13

abnormal vertebral arch morphology ( J:195156 )

• disorganization of vertebral processes and arches in the cervical vertebrae

abnormal vertebral transverse process morphology ( J:195156 )

• asymmetric fusion of transverse processes of the first 5 to 6 sacral vertebrae in 2 of 3 mice compared with 3 to 4 in wild-type mice

vertebral fusion ( J:195156 )

• resulting in tail kink

abnormal bone ossification ( J:195156 )

• disorganized and duplicated ossification centers in the lumbar and sacral region

nervous system

increased neuron apoptosis ( J:195156 )

• in the cortex and neural tube at E11.5 and E12.5

enlarged brain ventricles ( J:195156 )

• in perinatal mice

• however, lateral ventricle volume is normal

small hippocampus ( J:195156 )

• at E18.5

abnormal cerebral cortex morphology ( J:195156 )

• reduced size at E18.5

thin cerebral cortex ( J:195156 )

• in perinatal mice

limbs/digits/tail

decreased caudal vertebrae number ( J:195156 )

• 16 to 19 versus 20 to 22 in wild-type mice

kinked tail ( J:195156 )

• in most mice

• Background Sensitivity: subsequent backcrossing to C3H/HeH lowered the frequency of tail kinks to none by N3

vision/eye

delayed optic fissure closure ( J:195156 )

• at E12.5 and E14.5, all mice exhibit unilateral or bilateral delay in closure of the optic fissure

uveal coloboma ( J:195156 )

• uveal coloboma

microphthalmia ( J:195156 )

• more severe with internalization of the eye in some mice at E12.5 and E14.5

pigmentation

belly spot ( J:195156 )

• in most mice

• Background Sensitivity: subsequent backcrossing to C3H/HeH lowered the frequency of belly spotting to few mice by N3

growth/size/body

embryonic growth retardation ( J:195156 )

• Background Sensitivity: on a C57BL/6J background (no generation given)

hematopoietic system

abnormal erythropoiesis ( J:195156 )

• Background Sensitivity: at E13.5, mice on a C57BL/6J background (no generation given) exhibit a block and/or delay in erythroid precursor maturation compared with wild-type mice

cellular

increased neuron apoptosis ( J:195156 )

• in the cortex and neural tube at E11.5 and E12.5

integument

belly spot ( J:195156 )

• in most mice

• Background Sensitivity: subsequent backcrossing to C3H/HeH lowered the frequency of belly spotting to few mice by N3

embryo

embryonic growth retardation ( J:195156 )

• Background Sensitivity: on a C57BL/6J background (no generation given)

Allelic Composition	Rps7^Zma/Rps7⁺ Sox10^tm1Weg/Sox10⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps7^Zma mutation (0 available); any Rps7 mutation (16 available)
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Rps7^Zma/Rps7⁺ Sox10^tm1Weg/Sox10⁺ embryos show greatly reduced melanoblast number at E12.5 as compared to E12.5 Sox10^tm1Weg/Sox10⁺ mice

pigmentation

belly spot ( J:195156 )

• increased compared to in Rps7^Zma heterozygotes

hypopigmentation ( J:195156 )

• increased compared to in Sox10^tm1Weg heterozygotes without dark skin on the foot pads and tail

limbs/digits/tail

kinked tail ( J:195156 )

growth/size/body

decreased body size ( J:195156 )

nervous system

abnormal melanoblast morphology ( J:195156 )

• reduced numbers in the head and trunk at E12.5, more so than in Rps7^Zma heterozygotes

integument

belly spot ( J:195156 )

• increased compared to in Rps7^Zma heterozygotes

embryo

abnormal melanoblast morphology ( J:195156 )

• reduced numbers in the head and trunk at E12.5, more so than in Rps7^Zma heterozygotes

Allelic Composition	Rps7^Zma/Rps7⁺ Trp53^tm1Tyj/Trp53⁺
Genetic Background	involves: 129S2/SvPas * BALB/c * C3H/HeH * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps7^Zma mutation (0 available); any Rps7 mutation (16 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (235 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Increased apoptosis in the developing central nervous system of Rps7^Zma/Rps7⁺ embryos which is reduced in Rps7^Zma/Rps7⁺ Trp53^tm1Tyj/Trp53⁺ embryos

mortality/aging

mortality/aging ( J:195156 )

N	• viability is restored compared to in Rps7^Zma heterozygotes

pigmentation

belly spot ( J:195156 )

• small belly spot in some mice

embryo

embryo phenotype ( J:195156 )

N	• embryonic developmental delay observed in Rps7^Zma heterozygotes is suppressed

hematopoietic system

hematopoietic system phenotype ( J:195156 )

N	• erythroid maturation defects observed in Rps7^Zma heterozygotes are suppressed

integument

belly spot ( J:195156 )

• small belly spot in some mice

limbs/digits/tail

limbs/digits/tail phenotype ( J:195156 )

N	• tail kinks observed in Rps7^Zma heterozygotes are suppressed

nervous system

nervous system phenotype ( J:195156 )

N	• neuron apoptosis observed in Rps7^Zma heterozygotes is suppressed

skeleton

skeleton phenotype ( J:195156 )

N	• vertebral fusions observed in Rps7^Zma heterozygotes are suppressed

Allelic Composition	Rps7^Zma/Rps7⁺ Tg(Dct-lacZ)IPav/0
Genetic Background	involves: BALB/c * C3H/HeH * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps7^Zma mutation (0 available); any Rps7 mutation (16 available)
Tg(Dct-lacZ)IPav mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Melanoblast numbers are reduced in Rps7^Zma/Rps7⁺ Tg(Dct-lacZ)IPav/0 mice

embryo

abnormal melanoblast morphology ( J:195156 )

• reduced numbers in the head and trunk at E12.5 and E14.5

nervous system

abnormal melanoblast morphology ( J:195156 )

• reduced numbers in the head and trunk at E12.5 and E14.5

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