All Phenotypes Wdr35<yeti> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wdr35^yeti/Wdr35^yeti	Not Specified	MGI:5501229
ht2	Wdr35^{tm2a(EUCOMM)Hmgu}/Wdr35^yeti	involves: C57BL/6N	MGI:5501228

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:171617 )

• mice die before late E12.5

embryo

absent embryonic cilia ( J:171617 )

• on mouse embryonic fibroblasts derived from E11.5 embryos

abnormal direction of embryo turning ( J:171617 )

• randomized

delayed embryo turning ( J:171617 )

impaired somite development ( J:171617 )

• mice exhibit failure of somite derivatives, including putative ribs, to migrate and properly differentiate

cardiovascular system

abnormal direction of heart looping ( J:171617 )

• randomized and mislooped

abnormal heart tube morphology ( J:171617 )

• randomized and mislooped

respiratory system

tracheoesophageal fistula ( J:171617 )

pulmonary hypoplasia ( J:171617 )

homeostasis/metabolism

edema ( J:171617 )

• generalized

skeleton

absent ribs ( J:171617 )

muscle

diaphragmatic hernia ( J:171617 )

limbs/digits/tail

polysyndactyly ( J:171617 )

• in rare surviving, later-staged embryos

digestive/alimentary system

tracheoesophageal fistula ( J:171617 )

cellular

absent embryonic cilia ( J:171617 )

• on mouse embryonic fibroblasts derived from E11.5 embryos

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
short-rib thoracic dysplasia 7 with or without polydactyly		DOID:0110090	OMIM:614091	J:171617

Allelic Composition	Wdr35^{tm2a(EUCOMM)Hmgu}/Wdr35^yeti
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wdr35^{tm2a(EUCOMM)Hmgu} mutation (0 available); any Wdr35 mutation (70 available)
Wdr35^yeti mutation (0 available); any Wdr35 mutation (70 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryo development ( J:171617 )

• non-complementation of phenotypes observed in Wdr35^yeti homozygotes

impaired somite development ( J:171617 )

• failure of migration and differentiation of somite derivatives

skeleton

absent ribs ( J:171617 )

• absent or shortened

short ribs ( J:171617 )

• absent or shortened

limbs/digits/tail

polysyndactyly ( J:171617 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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