Phenotypes associated with this allele

• Allele Symbol: Stard10^tm1Saaa
• Allele Name: targeted mutation 1, Satomi Adachi-Akahane
• Allele ID: MGI:5500937
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stard10^tm1Saaa/Stard10^tm1Saaa	B6.Cg-Stard10^tm1Saaa	MGI:5500942

Genotype
MGI:5500942

hm1

• Allelic Composition: Stard10^tm1Saaa/Stard10^tm1Saaa
• Genetic Background: B6.Cg-Stard10^tm1Saaa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating cholesterol level ( J:198860 )

• in mice fed a high-fat diet

decreased circulating free fatty acids level ( J:198860 )

• in mice fed a high-fat diet

decreased circulating triglyceride level ( J:198860 )

• in mice fed a high-fat diet

abnormal bile salt homeostasis ( J:198860 )

• conjugation of bile acids is up-regulated in mice fed a normal diet

• enhanced bile acid secretion in mice fed a normal diet

• decreased intestinal absorption of bile acids in mice fed a normal diet

• enhanced fecal excretion of bile acid in mice fed a normal diet

increased bile salt level ( J:198860 )

• in mice fed a normal diet

decreased liver cholesterol level ( J:198860 )

• in mice fed a high-fat diet

abnormal phospholipid level ( J:198860 )

• increased phospholipid content in the liver membrane fraction in mice fed a high-fat diet

decreased liver triglyceride level ( J:198860 )

• in mice fed a high-fat diet

liver/biliary system

decreased liver cholesterol level ( J:198860 )

• in mice fed a high-fat diet

decreased liver triglyceride level ( J:198860 )

• in mice fed a high-fat diet

decreased liver weight ( J:198860 )

• in mice fed a high-fat diet

decreased susceptibility to diet-induced hepatic steatosis ( J:198860 )

• in mice fed a high-fat diet

abnormal bile secretion ( J:198860 )

• enhanced bile acid secretion in mice fed a normal diet

abnormal bile composition ( J:198860 )

• lower cholic acid levels in mice fed a normal diet

• conjugation of bile acids is up-regulated in mice fed a normal diet

digestive/alimentary system

abnormal digestive system physiology ( J:198860 )

• decreased intestinal absorption of bile acids in mice fed a normal diet

• enhanced fecal excretion of bile acid in mice fed a normal diet