All Phenotypes Cul4b<tm1.1Yxg> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Cul4b^tm1.1Yxg/Cul4b⁺	involves: 129X1/SvJ * FVB/N	MGI:5501033
ot2	Cul4b^tm1.1Yxg/Y	involves: 129X1/SvJ * FVB/N	MGI:5501032

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Growth retardation of Cul4b^tm1.1Yxg/Cul4b⁺ embryos

mortality/aging

lethality during fetal growth through weaning, incomplete penetrance ( J:199139 )

• fewer than expected mice are recovered at weaning

lethality throughout fetal growth and development, incomplete penetrance ( J:199139 )

• fewer than expected mice are present at E14.5

embryo

embryonic growth retardation ( J:199139 )

• at E9.5, E10.5 and E12.5

decreased embryo size ( J:199139 )

• at E9.5, E10.5 and E12.5

abnormal placenta labyrinth morphology ( J:199139 )

• more loosely formed than in wild-type mice

disorganized placental labyrinth ( J:199139 )

• deeply invaded by the spongiotrophoblast layer unlike in wild-type mice

small placenta ( J:199139 )

pale placenta ( J:199139 )

abnormal visceral yolk sac morphology ( J:199139 )

• not well developed at E12.5 and reduced blood flow at E12.5

growth/size/body

embryonic growth retardation ( J:199139 )

• at E9.5, E10.5 and E12.5

decreased embryo size ( J:199139 )

• at E9.5, E10.5 and E12.5

decreased body size ( J:199139 )

• in newborn mice

• the difference is narrow in adult mice

decreased body weight ( J:199139 )

• in newborn mice

• the difference is narrow in adult mice

postnatal growth retardation ( J:199139 )

decreased fetal size ( J:199139 )

• at E14.5

fetal growth retardation ( J:199139 )

• at E14.5

cellular

abnormal dosage compensation, by inactivation of X chromosome ( J:199139 )

• skewed towards the targeted allele

integument

pallor ( J:199139 )

• at E12.5 and E14.5

Allelic Composition	Cul4b^tm1.1Yxg/Y
Genetic Background	involves: 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul4b^tm1.1Yxg mutation (0 available); any Cul4b mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Early developmental arrest in Cul4b^tm1.1Yxg/Y embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:199139 )

• no mice are recovered after E9.5

embryo

increased embryonic tissue cell apoptosis ( J:199139 )

• in E7.5 embryos

embryonic growth retardation ( J:199139 )

decreased embryo size ( J:199139 )

• at E7.5 to E8.5

abnormal embryonic tissue morphology ( J:199139 )

• the embryonic part of the cylinder is not expanded and boundaries between germ layers are indiscernible unlike in wild-type mice

abnormal extraembryonic tissue morphology ( J:199139 )

• under developed and disorganized

disorganized extraembryonic tissue ( J:199139 )

growth/size/body

embryonic growth retardation ( J:199139 )

decreased embryo size ( J:199139 )

• at E7.5 to E8.5

cellular

increased embryonic tissue cell apoptosis ( J:199139 )

• in E7.5 embryos

decreased cell proliferation ( J:199139 )

• in E7.5 embryos

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