Phenotypes associated with this allele

• Allele Symbol: Dbn1^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5501061
• Summary: 20 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dbn1^tm1b(KOMP)Wtsi/Dbn1^tm1b(KOMP)Wtsi	C57BL/6NCrl-Dbn1^tm1b(KOMP)Wtsi/Wtsi	MGI:7414858
hm2	Dbn1^tm1b(KOMP)Wtsi/Dbn1^tm1b(KOMP)Wtsi	C57BL/6N-Dbn1^tm1b(KOMP)Wtsi/Bay	MGI:5756967
hm3	Dbn1^tm1b(KOMP)Wtsi/Dbn1^tm1b(KOMP)Wtsi	C57BL/6N-Dbn1^tm1b(KOMP)Wtsi/H	MGI:5756969
hm4	Dbn1^tm1b(KOMP)Wtsi/Dbn1^tm1b(KOMP)Wtsi	C57BL/6N-Dbn1^tm1b(KOMP)Wtsi/Ics	MGI:5756965
hm5	Dbn1^tm1b(KOMP)Wtsi/Dbn1^tm1b(KOMP)Wtsi	C57BL/6N-Dbn1^tm1b(KOMP)Wtsi/Ieg	MGI:5756964
hm6	Dbn1^tm1b(KOMP)Wtsi/Dbn1^tm1b(KOMP)Wtsi	C57BL/6N-Dbn1^tm1b(KOMP)Wtsi/J	MGI:5756968
hm7	Dbn1^tm1b(KOMP)Wtsi/Dbn1^tm1b(KOMP)Wtsi	C57BL/6N-Dbn1^tm1b(KOMP)Wtsi/MbpMmucd	MGI:6325128
hm8	Dbn1^tm1b(KOMP)Wtsi/Dbn1^tm1b(KOMP)Wtsi	C57BL/6N-Dbn1^tm1b(KOMP)Wtsi/Rbrc	MGI:5756966
hm9	Dbn1^tm1b(KOMP)Wtsi/Dbn1^tm1b(KOMP)Wtsi	C57BL/6N-Dbn1^tm1b(KOMP)Wtsi/Ucd	MGI:5756970
hm10	Dbn1^tm1b(KOMP)Wtsi/Dbn1^tm1b(KOMP)Wtsi	C57BL/6N-Dbn1^tm1b(KOMP)Wtsi/Wtsi	MGI:5631032
ht11	Dbn1^tm1b(KOMP)Wtsi/Dbn1^+	C57BL/6NCrl-Dbn1^tm1b(KOMP)Wtsi/Wtsi	MGI:7414857
ht12	Dbn1^tm1b(KOMP)Wtsi/Dbn1^+	C57BL/6N-Dbn1^tm1b(KOMP)Wtsi/Bay	MGI:5767624
ht13	Dbn1^tm1b(KOMP)Wtsi/Dbn1^+	C57BL/6N-Dbn1^tm1b(KOMP)Wtsi/H	MGI:5756959
ht14	Dbn1^tm1b(KOMP)Wtsi/Dbn1^+	C57BL/6N-Dbn1^tm1b(KOMP)Wtsi/Ics	MGI:5756963
ht15	Dbn1^tm1b(KOMP)Wtsi/Dbn1^+	C57BL/6N-Dbn1^tm1b(KOMP)Wtsi/Ieg	MGI:5756961
ht16	Dbn1^tm1b(KOMP)Wtsi/Dbn1^+	C57BL/6N-Dbn1^tm1b(KOMP)Wtsi/J	MGI:5756962
ht17	Dbn1^tm1b(KOMP)Wtsi/Dbn1^+	C57BL/6N-Dbn1^tm1b(KOMP)Wtsi/MbpMmucd	MGI:7471968
ht18	Dbn1^tm1b(KOMP)Wtsi/Dbn1^+	C57BL/6N-Dbn1^tm1b(KOMP)Wtsi/Rbrc	MGI:5759178
ht19	Dbn1^tm1b(KOMP)Wtsi/Dbn1^+	C57BL/6N-Dbn1^tm1b(KOMP)Wtsi/Ucd	MGI:5756960
ht20	Dbn1^tm1b(KOMP)Wtsi/Dbn1^+	C57BL/6N-Dbn1^tm1b(KOMP)Wtsi/Wtsi	MGI:5608363

Genotype
MGI:7414858

hm1

• Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6NCrl-Dbn1^{tm1b(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0211_3_A05

Data Sources

IMPC Data for Dbn1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

no spontaneous movement ( J:211773 )

IMPC - CCP-IMG

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - CCP-IMG

Genotype
MGI:5756967

hm2

• Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
• Cell Lines: EPD0211_3_A05

Data Sources

IMPC Data for Dbn1

behavior/neurological

unresponsive to tactile stimuli ( J:211773 )

IMPC - BCM

embryo

abnormal embryo size ( J:211773 )

IMPC - BCM

growth/size/body

abnormal embryo size ( J:211773 )

IMPC - BCM

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - BCM

Genotype
MGI:5756969

hm3

• Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/H
• Cell Lines: EPD0211_3_A05

Data Sources

IMPC Data for Dbn1

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - HAR

Genotype
MGI:5756965

hm4

• Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Ics
• Cell Lines: EPD0211_3_A05

Data Sources

IMPC Data for Dbn1

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - ICS

Genotype
MGI:5756964

hm5

• Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Ieg
• Cell Lines: EPD0211_3_A05

Data Sources

IMPC Data for Dbn1

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HMGU

Genotype
MGI:5756968

hm6

• Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/J
• Cell Lines: EPD0211_3_A05

Data Sources

IMPC Data for Dbn1

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:6325128

hm7

• Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/MbpMmucd
• Cell Lines: EPD0211_3_A05

Data Sources

IMPC Data for Dbn1

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

♂

IMPC - UCD

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - UCD

Genotype
MGI:5756966

hm8

• Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Rbrc
• Cell Lines: EPD0211_3_A05

Data Sources

IMPC Data for Dbn1

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - RBRC

Genotype
MGI:5756970

hm9

• Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Ucd
• Cell Lines: EPD0211_3_A05

Data Sources

IMPC Data for Dbn1

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

♂

IMPC - TCP

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - TCP

Genotype
MGI:5631032

hm10

• Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0211_3_A05

Data Sources

IMPC Data for Dbn1

cardiovascular system

dilated liver sinusoidal space ( J:239583 )

DMDD

craniofacial

abnormal hypoglossal canal morphology ( J:239583 )

DMDD

absent hypoglossal canal ( J:239583 )

DMDD

embryo

abnormal Wolffian duct connection ( J:239583 )

DMDD

liver/biliary system

dilated liver sinusoidal space ( J:239583 )

DMDD

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - WTSI

nervous system

abnormal brain white matter morphology ( J:239583 )

DMDD

abnormal brain internal capsule morphology ( J:239583 )

DMDD

abnormal forebrain morphology ( J:239583 )

DMDD

abnormal telencephalon morphology ( J:239583 )

DMDD

abnormal brachial plexus formation ( J:239583 )

DMDD

absent hypoglossal nerve ( J:239583 )

DMDD

thin hypoglossal nerve ( J:239583 )

DMDD

skeleton

abnormal hypoglossal canal morphology ( J:239583 )

DMDD

absent hypoglossal canal ( J:239583 )

DMDD

abnormal cervical rib ( J:239583 )

DMDD

Genotype
MGI:7414857

ht11

• Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺
• Genetic Background: C57BL/6NCrl-Dbn1^{tm1b(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0211_3_A05

Data Sources

IMPC Data for Dbn1

cardiovascular system

abnormal heart morphology ( J:211773 )

♂

IMPC - CCP-IMG

enlarged heart ( J:211773 )

♂

IMPC - CCP-IMG

growth/size/body

enlarged heart ( J:211773 )

♂

IMPC - CCP-IMG

homeostasis/metabolism

increased fasting circulating glucose level ( J:211773 )

IMPC - CCP-IMG

liver/biliary system

abnormal liver morphology ( J:211773 )

♂

IMPC - CCP-IMG

Genotype
MGI:5767624

ht12

• Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺
• Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
• Cell Lines: EPD0211_3_A05

Data Sources

IMPC Data for Dbn1

behavior/neurological

unresponsive to tactile stimuli ( J:211773 )

IMPC - BCM

decreased vertical activity ( J:211773 )

IMPC - BCM

cardiovascular system

enlarged heart ( J:211773 )

♂

IMPC - BCM

growth/size/body

enlarged heart ( J:211773 )

♂

IMPC - BCM

homeostasis/metabolism

decreased circulating cholesterol level ( J:211773 )

♂

IMPC - BCM

decreased circulating serum albumin level ( J:211773 )

♂

IMPC - BCM

Genotype
MGI:5756959

ht13

• Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺
• Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/H
• Cell Lines: EPD0211_3_A05

Data Sources

IMPC Data for Dbn1

skeleton

abnormal vertebrae morphology ( J:211773 )

♂

IMPC - HAR

Genotype
MGI:5756963

ht14

• Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺
• Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Ics
• Cell Lines: EPD0211_3_A05

Data Sources

IMPC Data for Dbn1

behavior/neurological

decreased grip strength ( J:211773 )

♂

IMPC - ICS

vision/eye

decreased total retina thickness ( J:211773 )

IMPC - ICS

Genotype
MGI:5756961

ht15

• Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺
• Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Ieg
• Cell Lines: EPD0211_3_A05

Data Sources

IMPC Data for Dbn1

hematopoietic system

increased red blood cell distribution width ( J:211773 )

♂

IMPC - HMGU

decreased mean platelet volume ( J:211773 )

♀

IMPC - HMGU

Genotype
MGI:5756962

ht16

• Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺
• Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/J
• Cell Lines: EPD0211_3_A05

Data Sources

IMPC Data for Dbn1

growth/size/body

increased lean body mass ( J:211773 )

♂

IMPC - JAX

homeostasis/metabolism

decreased circulating free fatty acids level ( J:211773 )

♂

IMPC - JAX

decreased circulating serum albumin level ( J:211773 )

♂

IMPC - JAX

Genotype
MGI:7471968

ht17

• Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺
• Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/MbpMmucd
• Cell Lines: EPD0211_3_A05

Data Sources

IMPC Data for Dbn1

adipose tissue

decreased total body fat amount ( J:211773 )

♂

IMPC - UCD

nervous system

increased prepulse inhibition ( J:211773 )

IMPC - UCD

skeleton

increased bone mineral content ( J:211773 )

♂

IMPC - UCD

Genotype
MGI:5759178

ht18

• Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺
• Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Rbrc
• Cell Lines: EPD0211_3_A05

Data Sources

IMPC Data for Dbn1

behavior/neurological

increased exploration in new environment ( J:211773 )

IMPC - RBRC

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:211773 )

♀

IMPC - RBRC

Genotype
MGI:5756960

ht19

• Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺
• Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Ucd
• Cell Lines: EPD0211_3_A05

Data Sources

IMPC Data for Dbn1

adipose tissue

decreased total body fat amount ( J:211773 )

IMPC - TCP

growth/size/body

increased lean body mass ( J:211773 )

IMPC - TCP

homeostasis/metabolism

increased circulating phosphate level ( J:211773 )

♂

IMPC - TCP

skeleton

increased bone mineral content ( J:211773 )

♂

IMPC - TCP

Genotype
MGI:5608363

ht20

• Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺
• Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0211_3_A05

Data Sources

IMPC Data for Dbn1

hematopoietic system

increased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

homeostasis/metabolism

increased circulating creatinine level ( J:211773 )

♂

IMPC - WTSI

increased circulating magnesium level ( J:211773 )

♂

IMPC - WTSI

increased circulating chloride level ( J:211773 )

♀

IMPC - WTSI

immune system

increased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI