All Phenotypes Dnase1l2<tm1.1(KOMP)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dnase1l2^{tm1.1(KOMP)Wtsi}
targeted mutation 1.1, Wellcome Trust Sanger Institute
MGI:5501065

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/Bay	MGI:5898574
hm2	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/H	MGI:5757009
hm3	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/Ieg	MGI:5757008
hm4	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/J	MGI:5757011
hm5	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/Orl	MGI:5757010
hm6	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/Ucd	MGI:5757007
hm7	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/Wtsi	MGI:5757006
ht8	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2⁺	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/Bay	MGI:5898573

Allelic Composition	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}
Genetic Background	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/Bay
Cell Lines	EPD0296_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnase1l2^{tm1.1(KOMP)Wtsi} mutation (3 available); any Dnase1l2 mutation (26 available)

Data Sources

IMPC Data for Dnase1l2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased grip strength ( J:211773 )

IMPC - BCM

cardiovascular system

abnormal heart left ventricle morphology ( J:211773 )

IMPC - BCM

decreased cardiac stroke volume ( J:211773 )

IMPC - BCM

craniofacial

abnormal maxilla morphology ( J:211773 )

IMPC - BCM

hematopoietic system

abnormal spleen morphology ( J:211773 )

IMPC - BCM

immune system

abnormal spleen morphology ( J:211773 )

IMPC - BCM

limbs/digits/tail

brachydactyly ( J:211773 )

IMPC - BCM

short tibia ( J:211773 )

IMPC - BCM

skeleton

abnormal maxilla morphology ( J:211773 )

IMPC - BCM

short tibia ( J:211773 )

IMPC - BCM

abnormal joint morphology ( J:211773 )

IMPC - BCM

Allelic Composition	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}
Genetic Background	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/H
Cell Lines	EPD0296_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnase1l2^{tm1.1(KOMP)Wtsi} mutation (3 available); any Dnase1l2 mutation (26 available)

Data Sources

IMPC Data for Dnase1l2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

IMPC - HAR

behavior/neurological

decreased grip strength ( J:211773 )

IMPC - HAR

decreased locomotor activity ( J:211773 )

IMPC - HAR

homeostasis/metabolism

increased blood urea nitrogen level ( J:211773 )

IMPC - HAR

limbs/digits/tail

abnormal digit morphology ( J:211773 )

IMPC - HAR

short tibia ( J:211773 )

IMPC - HAR

abnormal tail morphology ( J:211773 )

IMPC - HAR

skeleton

short tibia ( J:211773 )

IMPC - HAR

abnormal bone structure ( J:211773 )

IMPC - HAR

abnormal joint morphology ( J:211773 )

IMPC - HAR

vertebral fusion ( J:211773 )

IMPC - HAR

vision/eye

persistence of hyaloid vascular system ( J:211773 )

IMPC - HAR

Allelic Composition	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}
Genetic Background	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/Ieg
Cell Lines	EPD0296_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnase1l2^{tm1.1(KOMP)Wtsi} mutation (3 available); any Dnase1l2 mutation (26 available)

Data Sources

IMPC Data for Dnase1l2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased locomotor activity ( J:211773 )

IMPC - HMGU

abnormal vocalization ( J:211773 )

IMPC - HMGU

growth/size/body

decreased body length ( J:211773 )

IMPC - HMGU

homeostasis/metabolism

increased blood urea nitrogen level ( J:211773 )

IMPC - HMGU

increased fasting circulating glucose level ( J:211773 )

IMPC - HMGU

limbs/digits/tail

abnormal autopod morphology ( J:211773 )

IMPC - HMGU

abnormal digit morphology ( J:211773 )

IMPC - HMGU

short tibia ( J:211773 )

IMPC - HMGU

nervous system

abnormal optic disk morphology ( J:211773 )

IMPC - HMGU

skeleton

short tibia ( J:211773 )

IMPC - HMGU

vision/eye

abnormal optic disk morphology ( J:211773 )

IMPC - HMGU

abnormal lens morphology ( J:211773 )

IMPC - HMGU

cataract ( J:211773 )

IMPC - HMGU

Allelic Composition	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}
Genetic Background	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/J
Cell Lines	EPD0296_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnase1l2^{tm1.1(KOMP)Wtsi} mutation (3 available); any Dnase1l2 mutation (26 available)

Data Sources

IMPC Data for Dnase1l2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased heart weight ( J:211773 )

IMPC - JAX

growth/size/body

increased heart weight ( J:211773 )

IMPC - JAX

decreased body length ( J:211773 )

IMPC - JAX

homeostasis/metabolism

increased fasting circulating glucose level ( J:211773 )

IMPC - JAX

Allelic Composition	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}
Genetic Background	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/Orl
Cell Lines	EPD0296_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnase1l2^{tm1.1(KOMP)Wtsi} mutation (3 available); any Dnase1l2 mutation (26 available)

Data Sources

IMPC Data for Dnase1l2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:211773 )

IMPC - ICS

decreased grip strength ( J:211773 )

IMPC - ICS

decreased locomotor activity ( J:211773 )

IMPC - ICS

growth/size/body

abnormal head morphology ( J:211773 )

IMPC - ICS

decreased body length ( J:211773 )

IMPC - ICS

homeostasis/metabolism

increased circulating calcium level ( J:211773 )

IMPC - ICS

integument

abnormal nail morphology ( J:211773 )

IMPC - ICS

limbs/digits/tail

abnormal digit morphology ( J:211773 )

IMPC - ICS

short tibia ( J:211773 )

IMPC - ICS

abnormal tail morphology ( J:211773 )

IMPC - ICS

skeleton

short tibia ( J:211773 )

IMPC - ICS

vision/eye

persistence of hyaloid vascular system ( J:211773 )

IMPC - ICS

Allelic Composition	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}
Genetic Background	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/Ucd
Cell Lines	EPD0296_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnase1l2^{tm1.1(KOMP)Wtsi} mutation (3 available); any Dnase1l2 mutation (26 available)

Data Sources

IMPC Data for Dnase1l2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

IMPC - TCP

behavior/neurological

decreased grip strength ( J:211773 )

IMPC - TCP

craniofacial

abnormal cranium morphology ( J:211773 )

IMPC - TCP

growth/size/body

decreased body length ( J:211773 )

IMPC - TCP

limbs/digits/tail

abnormal digit morphology ( J:211773 )

IMPC - TCP

brachydactyly ( J:211773 )

IMPC - TCP

short tibia ( J:211773 )

IMPC - TCP

nervous system

abnormal optic disk morphology ( J:211773 )

IMPC - TCP

skeleton

abnormal cranium morphology ( J:211773 )

IMPC - TCP

short tibia ( J:211773 )

IMPC - TCP

abnormal bone structure ( J:211773 )

IMPC - TCP

decreased bone mineral content ( J:211773 )

IMPC - TCP

vision/eye

abnormal eye morphology ( J:211773 )

IMPC - TCP

abnormal optic disk morphology ( J:211773 )

IMPC - TCP

Allelic Composition	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi}
Genetic Background	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/Wtsi
Cell Lines	EPD0296_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnase1l2^{tm1.1(KOMP)Wtsi} mutation (3 available); any Dnase1l2 mutation (26 available)

Data Sources

IMPC Data for Dnase1l2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

IMPC - UCD

increased total body fat amount ( J:211773 )

IMPC - WTSI

behavior/neurological

decreased grip strength ( J:211773 )

IMPC - WTSI

cardiovascular system

eye hemorrhage ( J:211773 )

IMPC - UCD

growth/size/body

decreased lean body mass ( J:211773 )

IMPC - WTSI

decreased body length ( J:211773 )

IMPC - WTSI

homeostasis/metabolism

increased circulating aspartate transaminase level ( J:211773 )

IMPC - WTSI

limbs/digits/tail

abnormal digit morphology ( J:211773 )

IMPC - WTSI

abnormal tibia morphology ( J:211773 )

IMPC - WTSI

short tibia ( J:211773 )

IMPC - UCD

abnormal tail morphology ( J:211773 )

IMPC - WTSI

skeleton

abnormal tibia morphology ( J:211773 )

IMPC - WTSI

short tibia ( J:211773 )

IMPC - UCD

abnormal spine curvature ( J:211773 )

IMPC - WTSI

abnormal bone structure ( J:211773 )

IMPC - UCD

decreased bone mineral content ( J:211773 )

IMPC - WTSI

abnormal joint morphology ( J:211773 )

IMPC - WTSI

fusion of vertebral arches ( J:211773 )

IMPC - WTSI

vision/eye

eye hemorrhage ( J:211773 )

IMPC - UCD

Allelic Composition	Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2⁺
Genetic Background	C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/Bay
Cell Lines	EPD0296_2_A10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnase1l2^{tm1.1(KOMP)Wtsi} mutation (3 available); any Dnase1l2 mutation (26 available)

Data Sources

IMPC Data for Dnase1l2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal stomach morphology ( J:211773 )

IMPC - BCM

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