All Phenotypes Nkx6-1<tm1.1Msan> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nkx6-1^tm1.1Msan
targeted mutation 1.1, Maike Sander
MGI:5501129

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nkx6-1^tm1Jlr/Nkx6-1^tm1.1Msan Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Tg(Ins2-cre)25Mgn/0	involves: 129 * C57BL/6 * DBA * SJL	MGI:5501188
cn2	Nkx6-1^tm1Jlr/Nkx6-1^tm1.1Msan Tg(CAG-Bgeo/GFP)21Lbe/0 Tg(Neurog3-cre)C1Able/0	involves: 129/Sv * C57BL/6 * SJL	MGI:5501186
cn3	Nkx6-1^tm1.1Msan/Nkx6-1⁺ Pdx1^tm1Cvw/Pdx1⁺ Tg(Neurog3-cre)C1Able/0	involves: 129/Sv * C57BL/6 * SJL	MGI:5501187

Allelic Composition	Nkx6-1^tm1Jlr/Nkx6-1^tm1.1Msan Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Tg(Ins2-cre)25Mgn/0
Genetic Background	involves: 129 * C57BL/6 * DBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(EYFP)Cos mutation (11 available); any Gt(ROSA)26Sor mutation (1005 available)
Nkx6-1^tm1.1Msan mutation (1 available); any Nkx6-1 mutation (4 available)
Nkx6-1^tm1Jlr mutation (0 available); any Nkx6-1 mutation (4 available)
Tg(Ins2-cre)25Mgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreatic beta cell differentiation ( J:195153 )

• maintenance of beta cell is impaired with conversion to delta cell fate

decreased pancreatic beta cell number ( J:195153 )

increased pancreatic delta cell number ( J:195153 )

cellular

abnormal pancreatic beta cell differentiation ( J:195153 )

• maintenance of beta cell is impaired with conversion to delta cell fate

Allelic Composition	Nkx6-1^tm1Jlr/Nkx6-1^tm1.1Msan Tg(CAG-Bgeo/GFP)21Lbe/0 Tg(Neurog3-cre)C1Able/0
Genetic Background	involves: 129/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx6-1^tm1.1Msan mutation (1 available); any Nkx6-1 mutation (4 available)
Nkx6-1^tm1Jlr mutation (0 available); any Nkx6-1 mutation (4 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation (2 available)
Tg(Neurog3-cre)C1Able mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:195153 )

• mice die within the first few days after birth

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:195153 )

N	• mice do not exhibit endocrine-to-acinar fate conversion • beta cells exhibit normal cell proliferation and apoptosis

abnormal pancreatic beta cell differentiation ( J:195153 )

• beta cell differentiation is impaired with insulin+ cells that are polyhormonal and ectopically express alpha cell markers unlike in control cells

increased pancreatic alpha cell number ( J:195153 )

decreased pancreatic beta cell number ( J:195153 )

• due to reduced differentiation without an effect on proliferation and apoptosis

increased pancreatic delta cell number ( J:195153 )

increased pancreatic epsilon cell number ( J:195153 )

homeostasis/metabolism

hyperglycemia ( J:195153 )

dehydration ( J:195153 )

cellular

abnormal pancreatic beta cell differentiation ( J:195153 )

• beta cell differentiation is impaired with insulin+ cells that are polyhormonal and ectopically express alpha cell markers unlike in control cells

Allelic Composition	Nkx6-1^tm1.1Msan/Nkx6-1⁺ Pdx1^tm1Cvw/Pdx1⁺ Tg(Neurog3-cre)C1Able/0
Genetic Background	involves: 129/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx6-1^tm1.1Msan mutation (1 available); any Nkx6-1 mutation (4 available)
Pdx1^tm1Cvw mutation (1 available); any Pdx1 mutation (35 available)
Tg(Neurog3-cre)C1Able mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:195153 )

• mice exhibit an increase in the glucagon to insulin cell ratio as in Pdx1^tm1Cvw heterozygotes

increased pancreatic alpha cell number ( J:195153 )

• as in Pdx1^tm1Cvw heterozygotes

decreased pancreatic beta cell number ( J:195153 )

• as in Pdx1^tm1Cvw heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24