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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nfkbiztm1.1Muta
targeted mutation 1.1, Tatsushi Muta
MGI:5501251
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Lyz2tm1(cre)Ifo/Lyz2+
Nfkbiztm1.1Muta/Nfkbiztm1.1Muta
involves: 129P2/OlaHsd * C57BL/6 MGI:5501492
cn2
Cd79atm1(cre)Reth/Cd79a+
Nfkbiztm1.1Muta/Nfkbiztm1.1Muta
involves: BALB/c * C57BL/6 MGI:5501491
cn3
Nfkbiztm1.1Muta/Nfkbiztm1.1Muta
Tg(KRT5-cre)1Tak/?
involves: C3H * C57BL/6 MGI:5501493
cn4
Nfkbiztm1.1Muta/Nfkbiztm1.1Muta
Tg(CAG-cre)13Miya/?
involves: C57BL/6 MGI:5501489
cn5
Nfkbiztm1.1Muta/Nfkbiztm1.1Muta
Tg(Lck-cre)1Jtak/?
involves: C57BL/6 MGI:5501490


Genotype
MGI:5501492
cn1
Allelic
Composition
Lyz2tm1(cre)Ifo/Lyz2+
Nfkbiztm1.1Muta/Nfkbiztm1.1Muta
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Nfkbiztm1.1Muta mutation (1 available); any Nfkbiz mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• lack inflammation up to 30 weeks of age




Genotype
MGI:5501491
cn2
Allelic
Composition
Cd79atm1(cre)Reth/Cd79a+
Nfkbiztm1.1Muta/Nfkbiztm1.1Muta
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Nfkbiztm1.1Muta mutation (1 available); any Nfkbiz mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• lack inflammation up to 30 weeks of age




Genotype
MGI:5501493
cn3
Allelic
Composition
Nfkbiztm1.1Muta/Nfkbiztm1.1Muta
Tg(KRT5-cre)1Tak/?
Genetic
Background
involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkbiztm1.1Muta mutation (1 available); any Nfkbiz mutation (33 available)
Tg(KRT5-cre)1Tak mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• inflammation present

vision/eye
• increased apoptosis

integument
• inflammation present

endocrine/exocrine glands
• increased apoptosis

cellular
• increased apoptosis




Genotype
MGI:5501489
cn4
Allelic
Composition
Nfkbiztm1.1Muta/Nfkbiztm1.1Muta
Tg(CAG-cre)13Miya/?
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkbiztm1.1Muta mutation (1 available); any Nfkbiz mutation (33 available)
Tg(CAG-cre)13Miya mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• swelling as early as 2 weeks of age
• inflammatory effects in all mice by 8 weeks

immune system
• mostly in the periocular region initially
• eventually spreads over the whole face, skin erosion and hair loss

integument
• mostly in the periocular region initially
• eventually spreads over the whole face, skin erosion and hair loss

homeostasis/metabolism
• swelling as early as 2 weeks of age
• inflammatory effects in all mice by 8 weeks

growth/size/body
• swelling as early as 2 weeks of age
• inflammatory effects in all mice by 8 weeks

craniofacial
• swelling as early as 2 weeks of age
• inflammatory effects in all mice by 8 weeks




Genotype
MGI:5501490
cn5
Allelic
Composition
Nfkbiztm1.1Muta/Nfkbiztm1.1Muta
Tg(Lck-cre)1Jtak/?
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkbiztm1.1Muta mutation (1 available); any Nfkbiz mutation (33 available)
Tg(Lck-cre)1Jtak mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• lack inflammation up to 30 weeks of age





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory