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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lman1tm1c(KOMP)Wtsi
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:5501339
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lman1tm1c(KOMP)Wtsi/Lman1tm1c(KOMP)Wtsi
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: C57BL/6 * C57BL/6J * C57BL/6N MGI:5607591
cn2
 		Lman1tm1c(KOMP)Wtsi/Lman1tm1c(KOMP)Wtsi
Tg(Tek-cre)12Flv/0 		involves: C57BL/6 * C57BL/6J * C57BL/6N MGI:5607596


Genotype
MGI:5607591
cn1
Allelic
Composition		 Lman1tm1c(KOMP)Wtsi/Lman1tm1c(KOMP)Wtsi
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: C57BL/6 * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lman1tm1c(KOMP)Wtsi mutation (0 available); any Lman1 mutation (22 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal blood homeostasis ( J:213133 )
• mice show a reduction of plasma coagulation factor V (FV) activity and a reduction in plasma FV antigen level
• however plasma coagulation factor VIII (FVIII) levels are normal




Genotype
MGI:5607596
cn2
Allelic
Composition		 Lman1tm1c(KOMP)Wtsi/Lman1tm1c(KOMP)Wtsi
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lman1tm1c(KOMP)Wtsi mutation (0 available); any Lman1 mutation (22 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal blood homeostasis ( J:213133 )
• mice show a reduction in plasma coagulation factor VIII (FVIII) activity levels
• however plasma coagulation factor V (FV) activity is normal

hematopoietic system
abnormal platelet morphology ( J:213133 )
• modest reduction in platelet FV antigen




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory