Phenotypes associated with this allele

• Allele Symbol: Sec24c^{tm1c(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:5501469
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Meox2^tm1(cre)Sor/Meox2^+ Sec24c^tm1c(EUCOMM)Wtsi/Sec24c^tm1c(EUCOMM)Wtsi	involves: 129S4/SvJaeSor * C57BL/6 * SJL	MGI:5896387
cn2	Ptf1a^tm1.1(cre)Cvw/Ptf1a^+ Sec24c^tm1c(EUCOMM)Wtsi/Sec24c^tm1c(EUCOMM)Wtsi	involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5896386
cn3	Sec24c^tm1c(EUCOMM)Wtsi/Sec24c^tm1c(EUCOMM)Wtsi Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: C57BL/6 * DBA * SJL	MGI:5896384
cn4	Sec24c^tm1c(EUCOMM)Wtsi/Sec24c^tm1c(EUCOMM)Wtsi Tg(Vil1-cre)997Gum/0	involves: C57BL/6 * SJL	MGI:5896385
cn5	Sec24c^tm1c(EUCOMM)Wtsi/Sec24c^tm1c(EUCOMM)Wtsi Tg(Tagln-cre)1Her/0	involves: C57BL/6 * SJL	MGI:5896388

Genotype
MGI:5896387

cn1

• Allelic Composition: Meox2^tm1(cre)Sor/Meox2⁺; Sec24c^{tm1c(EUCOMM)Wtsi}/Sec24c^{tm1c(EUCOMM)Wtsi}
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:232065 )

• all die before 2 weeks of age

Genotype
MGI:5896386

cn2

• Allelic Composition: Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺; Sec24c^{tm1c(EUCOMM)Wtsi}/Sec24c^{tm1c(EUCOMM)Wtsi}
• Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:232065 )

N • no defects in pancreas morphology are detected

growth/size/body

growth/size/body region phenotype ( J:232065 )

N • no abnormalities in growth or weight gain are detected on either a normal chow or high fat diet compared to diet-matched controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:232065 )

N • no differences in plasma cholesterol, triglyceride or insulin levels

Genotype
MGI:5896384

cn3

• Allelic Composition: Sec24c^{tm1c(EUCOMM)Wtsi}/Sec24c^{tm1c(EUCOMM)Wtsi}; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: C57BL/6 * DBA * SJL

growth/size/body

growth/size/body region phenotype ( J:232065 )

N • no abnormalities in growth or weight gain are detected on either a normal chow or high fat diet compared to diet-matched controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:232065 )

N • no differences in plasma cholesterol or triglyceride levels

Genotype
MGI:5896385

cn4

• Allelic Composition: Sec24c^{tm1c(EUCOMM)Wtsi}/Sec24c^{tm1c(EUCOMM)Wtsi}; Tg(Vil1-cre)997Gum/0
• Genetic Background: involves: C57BL/6 * SJL

growth/size/body

growth/size/body region phenotype ( J:232065 )

N • no abnormalities in growth or weight gain are detected on either a normal chow or high fat diet compared to diet-matched controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:232065 )

N • no differences in plasma cholesterol or triglyceride levels

Genotype
MGI:5896388

cn5

• Allelic Composition: Sec24c^{tm1c(EUCOMM)Wtsi}/Sec24c^{tm1c(EUCOMM)Wtsi}; Tg(Tagln-cre)1Her/0
• Genetic Background: involves: C57BL/6 * SJL

normal phenotype

no abnormal phenotype detected ( J:232065 )

• viable and fertile