Phenotypes associated with this allele

• Allele Symbol: Srxn1^tm1Mtol
• Allele Name: targeted mutation 1, Mireille B Toledano
• Allele ID: MGI:5501480
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Srxn1^tm1Mtol/Srxn1^tm1Mtol	either: B6.129S2-Srxn1^tm1Mtol or (involves: 129S2/SvPasCrl * C57BL/6)	MGI:5501508

Genotype
MGI:5501508

hm1

• Allelic Composition: Srxn1^tm1Mtol/Srxn1^tm1Mtol
• Genetic Background: either: B6.129S2-Srxn1^tm1Mtol or (involves: 129S2/SvPasCrl * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:199277 )

• mice treated with LPS exhibit increased lethality compared with wild-type mice

homeostasis/metabolism

increased circulating alanine transaminase level ( J:199277 )

• in LPS-treated mice

increased circulating aspartate transaminase level ( J:199277 )

• in LPS-treated mice

increased susceptibility to xenobiotic induced morbidity/mortality ( J:199277 )

• mice treated with LPS exhibit increased lethality compared with wild-type mice

immune system

increased susceptibility to endotoxin shock ( J:199277 )

• mice treated with LPS exhibit increased lethality and alanine and aspartate transaminase levels compared with wild-type mice