Phenotypes associated with this allele

• Allele Symbol: Spi1^tm4.1Dgt
• Allele Name: targeted mutation 4.1, Daniel G Tenen
• Allele ID: MGI:5501529
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spi1^tm4.1Dgt/Spi1^tm4.1Dgt	B6.129(Cg)-Spi1^tm4.1Dgt	MGI:5501530

Genotype
MGI:5501530

hm1

• Allelic Composition: Spi1^tm4.1Dgt/Spi1^tm4.1Dgt
• Genetic Background: B6.129(Cg)-Spi1^tm4.1Dgt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:196609 )

N • hematopoietic stem cells exhibit normal bone marrow homing

increased bone marrow cell number ( J:196609 )

increased hematopoietic stem cell number ( J:196609 )

abnormal hematopoietic stem cell physiology ( J:196609 )

• 13.6-fold reduction in functional long term hematopoietic stem cells

• hematopoietic stem cells exhibit increased cell-cycle activation compared with wild-type cells

• however, expression of the human gene rescues phenotype

increased hematopoietic stem cell proliferation ( J:196609 )

• with premature exhaustion of hematopoietic stem cells

• however, expression of the human gene rescues phenotype

cellular

abnormal cell cycle ( J:196609 )

• hematopoietic stem cells exhibit increased cell-cycle activation compared with wild-type cells

increased hematopoietic stem cell proliferation ( J:196609 )

• with premature exhaustion of hematopoietic stem cells

• however, expression of the human gene rescues phenotype